THE REACTIONS OF GOLD(0) WITH AMINO-ACIDS AND THE SIGNIFICANCE OF THESE REACTIONS IN THE BIOCHEMISTRY OF GOLD
THE REACTIONS OF GOLD(0) WITH AMINO-ACIDS AND THE SIGNIFICANCE OF THESE REACTIONS IN THE BIOCHEMISTRY OF GOLD
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DOI：
10.1016/s0020-1693(00)85035-5
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
STURROCK, RD
中科院分区：
文献类型：
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作者：
BROWN, DH;SMITH, WE;STURROCK, RD
金(0)溶于暴露在氧气中的多种氨基酸水溶液。特别是硫醇分子半胱氨酸、青霉胺和谷胱甘肽，给出了金的络合物溶液，可以用圆二色谱进行鉴定。动物实验表明，金的络合物很容易通过皮肤吸收。本文报道了长期接触金的人皮肤中金的浓度，以及用金(I)化合物Myocrisin治疗的患者皮肤中的金浓度。讨论了这些结果在珠宝腐蚀和皮肤刺激性反应方面的可能意义。
Gold(0) dissolves in a wide range of aqueous amino acid solutions exposed to dioxygen. In particular, the thiol-containing molecules cysteine, penicillamine and glutathione give solutions of gold complexes which can be identified by circular dichroism. Animal experiments suggest that gold complexes can be absorbed readily through skin. Gold concentration in human skin which had been in prolonged contact with gold and concentrations from the skin of patients treated with Myocrisin, a gold(I) compound, are reported. The possible significance of these results in terms of erosion of jewelry and skin-irritant reactions is discussed.