Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)
Cohort Profile: Extended Cohort for E-health, Environment and DNA (EXCEED)
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DOI：
10.1093/ije/dyz073
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发表时间：
2019-06-01
影响因子：
7.7
通讯作者：
Tobin, Martin D.
中科院分区：
文献类型：
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作者：
John, Catherine;Reeve, Nicola F.;Tobin, Martin D.
EXCEED旨在了解健康和疾病的遗传、环境和生活方式相关原因。像EXCEED这样的队列，广泛同意研究与疾病发作和进展以及药物反应相关的多种表型，通过提供可以识别、支持或反驳推定药物疗效或识别可能的不良反应的遗传证据，在药物开发中发挥作用。[1]此外，这些队列非常适合于研究多发性硬化症。多发性硬化症描述了一名患者存在多种疾病或病症，尽管文献中的定义差异很大。2-4它需要一个整体的方法来优化护理和避免医源性并发症，如药物相互作用。在许多卫生保健系统日益专业化和多Morphia患者使用高卫生保健的背景下，提供这种护理构成了一个复杂的挑战。5-7在高收入国家，多重死亡在较贫困的社会经济群体中特别常见，甚至可能被视为老年人的常态，8、9而全球人口老龄化和中低收入国家日益沉重的非传染性疾病负担加剧了其全球重要性。10.英国医学科学院最近召集的一个专家工作组强调，缺乏与负担、决定因素
EXCEED aims to develop understanding of the genetic, environmental and lifestyle-related causes of health and disease. Cohorts like EXCEED, with broad consent to study multiple phenotypes related to onset and progression of disease and drug response, have a role to play in medicines development, by providing genetic evidence that can identify, support or refute putative drug efficacy or identify possible adverse effects. 1 Furthermore, such cohorts are well suited to the study of multimorbidity. Multimorbidity describes the presence of multiple diseases or conditions in one patient, though definitions in the literature vary widely. 2–4 It demands a holistic approach to optimize care and avoid iatrogenic complications, such as drug interactions. In the context of increasing specialisation of many health care systems and high health care use among people with multimorbidity, providing such care poses a complex challenge. 5–7 In high-income countries, multimorbidity is particularly common among more deprived socioeconomic groups and may even be considered as the norm amongst older people, 8, 9 and an ageing global population and a growing burden of non-communicable diseases in low-and middle-income countries compound its global importance. 10 An expert working group convened by the UK Academy of Medical Sciences recently highlighted the lack of available evidence relating to the burden, determinants,