Urinary N-Terminal Fragment of Titin Reflects Muscle Damage After a Soccer Match in Male Collegiate Soccer Players
Urinary N-Terminal Fragment of Titin Reflects Muscle Damage After a Soccer Match in Male Collegiate Soccer Players
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DOI：
10.1519/jsc.0000000000003923
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发表时间：
2021-02-01
影响因子：
3.2
通讯作者：
Takahashi, Hideyuki
中科院分区：
文献类型：
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作者：
Tanabe, Yoko;Shimizu, Kazuhiro;Takahashi, Hideyuki
以往的研究表明，非侵入性尿肌联蛋白（U-肌联蛋白）浓度与血清肌酸激酶（CK）活性，一个经典的侵入性肌肉损伤标志物高度相关。这一发现表明，U-肌联蛋白可用于估计肌肉损伤。然而，这些结果是使用基于实验室的离心运动模型实现的。因此，目前还不清楚U-肌联蛋白是否可用于评估发生在野外运动项目中的肌肉损伤。因此，我们评估是否U-肌联蛋白浓度密切相关的血清CK活性后，足球比赛。17名大学生足球运动员（年龄：20 +/- 1岁;身高：172 +/- 6 cm;体重：65 +/- 5 kg;溜溜球间歇性恢复测试2级，1，135 +/- 196 m）完成了一场测试比赛（两个半场各45分钟，中间间隔15分钟的正常半场时间）。分别于赛前2小时、赛后30分钟、24小时、48小时测定尿肌联蛋白浓度、血清CK活性、反向运动跳跃能力、肌肉酸痛程度。U-肌联蛋白浓度和CK活性在24小时类似地增加，并在比赛后48小时恢复到基线值。此外，比赛后U-肌联蛋白浓度较基线变化的百分比与血清CK活性显著正相关（r = 0.82，p < 0.05）。这些结果表明，非侵入性标记物U-肌联蛋白可用于评估在野外运动项目，如足球比赛中的肌肉损伤状况。
Previous studies have demonstrated that noninvasive urinary N-terminal fragment of titin (U-titin) concentration highly correlates with serum creatine kinase (CK) activity, a classic invasive muscle damage marker. This finding indicates that U-titin could be used to estimate muscle damage. However, these results were achieved using a laboratory-based eccentric exercise model. Therefore, it remains unclear whether U-titin is useful for evaluating muscle damage occurring in field sports events. As a result, we evaluated whether U-titin concentration closely relates to serum CK activity after a soccer match. Seventeen collegiate soccer players (age: 20 +/- 1 year; height: 172 +/- 6 cm; body mass: 65 +/- 5 kg; Yo-Yo intermittent recovery test level 2, 1,135 +/- 196 m) completed a test match (2 halves of 45 minutes separated by 15 minutes of normal half-time). U-titin concentration, serum CK activity, countermovement jump performance, and muscle soreness were assessed 2 hours before the match and 30 minutes, 24 hours, and 48 hours after the match. U-titin concentrations and CK activity similarly increased at 24 hours and returned to the baseline value at 48 hours after the match. Moreover, the percentage of changes in U-titin concentration from baseline after the match significantly and positively correlated with serum CK activity (r = 0.82, p < 0.05). These results suggest that the noninvasive marker U-titin can be used to assess muscle damage conditions in field sports events, such as soccer matches.