Hyperparathyroidism in metastases of prostatic carcinoma: a biochemical, hormonal and histomorphometric study.
Hyperparathyroidism in metastases of prostatic carcinoma: a biochemical, hormonal and histomorphometric study.
复制标题
前列腺癌转移中的甲状旁腺功能亢进：一项生化、激素和组织形态学研究。
作者：
H. Rico;A. Uson;E. Hernández;P. Prados;P. Páramo;J. Cabranes
继发性甲状旁腺功能亢进可能是前列腺癌骨转移的结果，但尚未从生物化学、激素状态和组织形态计量学多个方面进行研究。在20例D期前列腺癌患者中，进行了髂间骨活检用于组织形态计量学研究。通过放射免疫测定法测定了所有患者的分子甲状旁腺激素（PTH-M）和骨钙素以及其他被认为是骨重建生物标志物的参数。在这20例患者中，只有2例（10%）PTH-M升高（240 +/- 20.6 pmol/l），与其他18例（58.6 +/- 11.7 pmol/l）和对照组（60.4 +/- 7.2 pmol/l）显著不同。高甲状旁腺激素血症患者校正钙水平低（7.8 +/- 0.4 mg/dl），与正常PTH-M患者相比（9.2 ± 0.5 mg/dl，p <0.001），血清磷也是如此（分别为2.2 +/- 0.6 vs. 3.2 +/- 0.3和3.4 +/- 0.4 mg/dl，p <0.001）。与对照组相比，患者组的碱性磷酸酶升高（p <0.001），高PTH-M组的碱性磷酸酶更高（362 +/- 58 vs. 224 +/- 62 U/l，p <0.001）。（250字处删节）
Secondary hyperparathyroidism can develop as a result of bone metastases from prostatic cancer, but this has not been studied from the multiple aspects of biochemistry, hormonal status and histomorphometry. In 20 patients with stage-D prostatic cancer, a transiliac bone biopsy was performed for histomorphometric study. In all of them, molecular parathormone (PTH-M) and osteocalcin were determined by radioimmunoassay together with other parameters considered to be biological markers of bone remodelling. Of these 20 patients, only 2 (10%) had elevated PTH-M (240 +/- 20.6 pmol/l), differing significantly from the other 18 (58.6 +/- 11.7 pmol/l) and from controls (60.4 +/- 7.2 pmol/l). In the high PTH-M patients, corrected calcium was low (7.8 +/- 0.4 mg/dl) as compared to normal PTH-M patients (9.2 +/- 0.5 mg/dl, p less than 0.001), and this was also the case for serum phosphorus (2.2 +/- 0.6 vs. 3.2 +/- 0.3 and 3.4 +/- 0.4 mg/dl, respectively p less than 0.001). Alkaline phosphatase was raised in the patient groups as compared to controls (p less than 0.001) and was higher in the high PTH-M group (362 +/- 58 vs. 224 +/- 62 U/l, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)