Evaluating upper limb impairments in multiple sclerosis by exposure to different mechanical environments.
Evaluating upper limb impairments in multiple sclerosis by exposure to different mechanical environments.
复制标题
DOI：
10.1038/s41598-018-20343-y
复制
发表时间：
2018-02-01
影响因子：
4.6
通讯作者：
Casadio M
中科院分区：
文献类型：
--
作者：
Pellegrino L;Coscia M;Muller M;Solaro C;Casadio M
多发性硬化症是一种慢性自身免疫性神经退行性疾病，影响多个功能系统，导致与肌肉无力和缺乏运动协调相关的运动障碍。我们通过基于机器人的评估（包括行为和肌肉协同分析）对 11 名轻度至中度上肢损伤的多发性硬化症受试者（9 名女性；50±10 岁）与 11 名年龄和性别匹配的对照组（9 名女性；50±9 岁）进行了量化上肢运动缺陷。所有受试者通过移动上肢或在抓住机器人操作器手柄的同时施加力来执行平面到达任务，该机器人操作器产生四种不同的环境：自由空间、辅助或阻力以及刚性约束。我们记录了 15 块上半身肌肉的活动。多发性硬化症受试者产生不规则的轨迹。虽然孤立的手臂肌肉的活动看起来总体正常，但肩部肌肉与手臂运动的协调受到损害，并且在伸展运动中二头肌和三头肌有明显的共同激活。还观察到肌肉协同作用的时间和组织的系统差异。这项研究支持新生物标志物的定义和改善多发性硬化症上肢运动协调性的康复治疗。
Multiple sclerosis is a chronic, autoimmune and neurodegenerative disease affecting multiple functional systems and resulting in motor impairments associated with muscle weakness and lack of movement coordination. We quantified upper limb motor deficits with a robot-based assessment including behavioral and muscle synergy analysis in 11 multiple sclerosis subjects with mild to moderate upper limb impairment (9 female; 50 ± 10 years) compared to 11 age- and gender- matched controls (9 female; 50 ± 9 years). All subjects performed planar reaching tasks by moving their upper limb or applying force while grasping the handle of a robotic manipulandum that generated four different environments: free space, assistive or resistive forces, and rigid constraint. We recorded the activity of 15 upper body muscles. Multiple sclerosis subjects generated irregular trajectories. While activities in isolated arm muscles appeared generally normal, shoulder muscle coordination with arm motions was impaired and there was a marked co-activation of the biceps and triceps in extension movements. Systematic differences in timing and organization of muscle synergies have also been observed. This study supports the definition of new biomarkers and rehabilitative treatments for improving upper limb motor coordination in multiple sclerosis.
登录
查看更多内容
影响因子：
5.3
作者：
d'Avella, Andrea;Portone, Alessandro;Lacquaniti, Francesco
通讯作者：
Lacquaniti, Francesco
影响因子：
2.5
作者：
d'Avella, Andrea;Fernandez, Laure;Lacquaniti, Francesco
通讯作者：
Lacquaniti, Francesco
DOI：
10.1109/tnsre.2012.2187462
发表时间：
2012-05-01
影响因子：
4.9
作者：
Carpinella, Ilaria;Cattaneo, Davide;Ferrarin, Maurizio
通讯作者：
Ferrarin, Maurizio
影响因子：
2.5
作者：
FLANDERS, M;HERRMANN, U
通讯作者：
HERRMANN, U
影响因子：
2.9
作者：
Barroso FO;Torricelli D;Bravo-Esteban E;Taylor J;Gómez-Soriano J;Santos C;Moreno JC;Pons JL
通讯作者：
Pons JL