The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain
The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain
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DOI：
10.1213/01.ane.0000149546.97299.a2
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发表时间：
2005-05-01
影响因子：
5.7
通讯作者：
Goto, F
中科院分区：
文献类型：
--
作者：
Obata, H;Saito, S;Goto, F
抗抑郁药通常用于治疗神经性疼痛。在本研究中，我们确定了选择性单胺再摄取抑制剂在神经性疼痛大鼠脊髓模型中的抗异动作用。机械性异常痛是通过左L5和L6脊髓神经的紧密结扎产生的，并通过将von Frey纤维应用于左后爪来确定。5 -羟色胺去甲肾上腺素再摄取抑制剂milnacpran，选择性5 -羟色胺再摄取抑制剂paroxetine，或选择性去甲肾上腺素再摄取抑制剂maprotinine，通过长期植入导管给予鞘内注射。米尔那西普兰在3 ~ 100 μ g剂量范围内均产生剂量依赖性的抗异动作用，100 μ g后作用持续7 h （P < 0.05）。30 μ g的抗心律失常作用
Antidepressants are often used to treat neuropathic pain. In the present study, we determined the antiallodynic effects of selective monoamine reuptake inhibitors in the spinal cord in a rat model of neuropathic pain. Mechanical allodynia was produced by tight ligation of the left L5 and L6 spinal nerves and determined by applying von Frey filaments to the left hindpaw. A serotonin noradrenaline reuptake inhibitor, milnacipran, a selective serotonin reuptake inhibitor, paroxetine, or a selective noradrenaline reuptake inhibitor, maprotiline, was administered intrathecally via a chronically implanted catheter. Milnacipran produced dose-dependent antiallodynic effects at doses between 3 mu g and 100 mu g. The effect lasted for 7 h after injection of 100 mu g (P < 0.05). The antiallodynic effect of 30 mu g of