Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland
Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland
复制标题
锌指转录因子Slug在唾液腺腺样囊性癌中的表达及重要性
DOI：
10.1111/j.1600-0714.2010.00913.x
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Chen, Yu
中科院分区：
文献类型：
--
作者：
Tang, Yaling;Liang, Xinhua;Chen, Yu
背景：锌指转录因子Slug在肿瘤的增殖分化、复发、侵袭转移和降低生存率等方面发挥着重要作用。然而，关于Slug在唾液腺样囊性癌（ACC）中的表达和作用的信息很少。方法：回顾性分析1996 ~ 2005年四川大学华西口腔医院口腔颌面外科121例涎腺型ACC患者的人口学变量、原发肿瘤部位、诊断日期、神经周围侵犯、局部复发及远处转移情况。采用免疫组织化学方法检测所有病例的Slug表达。采用卡方检验分析Slug表达与临床病理变量的相关性，采用单因素和多因素分析检验预后因素。结果：Slug阳性表达率为71.90%（87/121）。Slug的表达与ACC患者的肿瘤部位、TNM分期、组织学类型、神经周围浸润、局部复发和远处转移相关（P < 0.05）。Slug表达、局部复发和远处转移是所有患者独立且重要的预后因素。结论：提示Slug可能在ACC的侵袭和转移中发挥重要作用，并且Slug可能是ACC患者发病时较强的侵袭和转移指标之一。
Background:It has been reported that zinc-finger transcription factor Slug plays a critical role in tumor proliferation and differentiation, relapse, invasion, metastasis, and decreased survival. However, there is little information on the expression and role of Slug in salivary adenoid cystic carcinoma (ACC).Method:Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC treated at the Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University between 1996 and 2005 were retrieved. The Slug expression of all these cases was examined by immunohistochemical methods. The association between Slug expression and clinicopathological variables was analyzed using Chi-squared test, and the prognostic factors were examined by univariate and multivariate analyses.Results:Our data demonstrated that the positive expression of Slug was observed in 71.90% (87/121) of cases. Slug expression was significantly associated with tumor site, TNM stage, histological pattern, perineural invasion, local regional recurrence and distant metastasis of patients with ACC (P < 0.05). And Slug expression, local regional recurrence and distant metastasis were independent and significant prognostic factors in all patients.Conclusions:It is proposed that Slug may play an important role in the invasion and metastasis of ACC, and that Slug had the potential for one of the strong invasion and metastasis indicators at presentation of ACC patients.