On the origin of MADS-domain transcription factors
On the origin of MADS-domain transcription factors
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DOI：
10.1016/j.tig.2010.01.004
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发表时间：
2010-04-01
影响因子：
11.4
通讯作者：
Theissen, Gunter
中科院分区：
文献类型：
--
作者：
Gramzow, Lydia;Ritz, Markus S.;Theissen, Gunter
MADS结构域转录因子参与植物、动物和真菌的信号转导和发育调控。因为它们的多样性与多细胞真核生物中新奇事物的起源有关，MADS结构域蛋白的早期进化令人感兴趣，但仍然是个谜。利用全基因组序列信息和远程同源性检测方法，我们证明MADS结构域起源于拓扑异构酶IIA亚基A的一个区域。此外，我们提供的证据表明，基因复制发生在血统，导致现存的真核生物的MRCA，引起SRF样和MEF2样MADS盒基因。
MADS-domain transcription factors are involved in signal transduction and developmental control in plants, animals and fungi. Because their diversification is linked to the origin of novelties in multicellular eukaryotes, the early evolution of MADS-domain proteins is of interest, but has remained enigmatic. Employing whole genome sequence information and remote homology detection methods, we demonstrate that the MADS domain originated from a region of topoisomerases IIA subunit A. Furthermore, we provide evidence that gene duplication occurred in the lineage that led to the MRCA of extant eukaryotes, giving rise to SRF-like and MEF2-like MADS-box genes.