Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone
Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone
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DOI：
10.1016/j.biortech.2005.07.006
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发表时间：
2006-08-01
影响因子：
11.4
通讯作者：
Lee, H. S.
中科院分区：
文献类型：
--
作者：
Lee, H. S.
用血小板聚集仪测定了姜黄提取物的抗血小板活性，并与抗血小板药物阿司匹林进行了比较。从姜黄根茎中分离得到活性成分，经多种光谱分析鉴定为姜黄酮。在半数抑制浓度(IC50)时，姜黄酮能有效地抑制胶原(IC50，14.4mU)和花生四烯酸(IC50，43.6mU)诱导的血小板聚集。而姜黄酮对血小板活化因子和凝血酶诱导的血小板聚集无影响。比较而言，姜黄酮对胶原诱导的血小板聚集的抑制作用明显强于阿司匹林。上述结果提示，姜黄酮可作为先导化合物抑制胶原和花生四烯酸诱导的血小板聚集。(C)2005爱思唯尔有限公司。保留所有权利。
The antiplatelet activities of Curcuma longa L. rhizome-derived materials were measured using a platelet aggregometer and compared with those of aspirin as antiplatelet agent. The active constituent from the rhizome of Curcuma longa L. was isolated and characterized as ar-turmerone by various spectral analyses. At 50% inhibitory concentration (IC50) value, ar-turmerone was effective in inhibiting platelet aggregation induced by collagen (IC50, 14.4 mu M) and arachidonic acid (IC50, 43.6 mu M). However, ar-turmerone had no effect on platelet activating factor or thrombin induced platelet aggregation. In comparison, ar-turmerone was significantly more potent platelet inhibitor than aspirin against platelet aggregation induced by collagen. These results suggested that ar-turmerone could be useful as a lead compound for inhibiting platelet aggregation induced by collagen and arachidonic acid. (c) 2005 Elsevier Ltd. All rights reserved.