Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise
Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise
复制标题
AICAR 和运动可改善接受高脂肪饮食和皮质酮联合治疗的小鼠的抑郁样行为
DOI：
10.1016/j.jad.2013.11.025
复制
发表时间：
2014-03-01
影响因子：
6.6
通讯作者：
Ji, Liu
中科院分区：
文献类型：
--
作者：
Liu, Weina;Zhai, Xiaofeng;Ji, Liu
重度抑郁症（MOD）和2型糖尿病（T2 DM）是高度共病的，两者之间可能存在双向联系。在此，我们已经描述了一个抑郁样和胰岛素抵抗（INSULIN）状态诱导的高脂饮食（HUD）和皮质酮（CURT）的共同治疗的小鼠模型。5-氨基咪唑-4-甲酰胺呋喃核糖苷（AICAR）是AMP激活蛋白激酶（AMPK）的药理学激活剂，最初用于改善胰岛素抵抗（IR）。有趣的是，我们的研究结果表明AICAR作为一种推定的抗抑郁药对DIR小鼠具有明显的潜力。与传统的抗抑郁药相比。AICAR作为一种有前途的抗抑郁药，避免了在长期HUD的背景下降低骨骼肌的胰岛素作用。运动也产生抗抑郁作用。我们的数据表明，AICAR和运动对DlR的影响可能会进一步增加我们对抑郁症和糖尿病之间联系的理解。(C)2013爱思唯尔有限公司版权所有。
Major depressive disorder (MOD) and type II diabetes mellitus (T2DM) are highly co-morbid, and there may be a bi-directional connection between the two. Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HUD) and corticosterone (CURT). 5-Aminoimidazole-4-carboxamide 1 d ribofuranoside (AICAR), a pharmacological activator of AMP-activated protein kinase (AMPK), was originally used to improve insulin resistance (IR). Interestingly, our results show a clear potential for AICAR as a putative antidepressant with a chronic action on the DlR mice. In contrast to the traditional antidepressants. AICAR as a promising antidepressant avoids reducing insulin actions of skeletal muscle in the context of long-term HUD. Exercise also produced antidepressant effects. Our data suggest that the effects of AICAR and exercise on DlR may further increase our understanding on the link between depression and diabetes. (C) 2013 Elsevier B.V. All rights reserved.