Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.
Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.
复制标题
血小板激活因子(PAF):细胞间相互作用中的信号传导和粘附。
DOI:
10.1007/978-1-4899-0179-8_47
复制
发表时间:
1996
影响因子:
--
通讯作者:
R. Whatley
中科院分区:
文献类型:
--
作者:
G. Zimmerman;M. Elstad;D. Lorant;T. McIntyre;S. Prescott;M. Topham;A. Weyrich;R. Whatley
Signalling by PAF is closely linked to adhesive interactions between cells of the inflammatory and vascular systems. It acts as a juxtacrine signal that alters the activity of beta 2 integrins on myeloid leukocytes (Figure 1), and works in concert with P-selectin at the surfaces of endothelial cells (Figure 2 and text). Observations in models of flow and in vivo support the original experiments using cultured endothelium under static conditions that indicated that PAF acts at this vascular interface. P-selectin modifies and integrates signals delivered through the PAF receptor on monocytes (Figure 4). Adhesion via P-selectin and engagement of beta 2 integrins modify signals leading to PAF synthesis (text and Figure 5). The intimate relationship between adhesive events and signalling by PAF may be a critical determinant in its roles in physiologic and pathologic responses.
登录
查看更多内容
影响因子:
15.9
作者:
WEYRICH, AS;MCINTYRE, TM;ZIMMERMAN, GA
通讯作者:
ZIMMERMAN, GA
DOI:
--
发表时间:
1992
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Zhou,W;Javors,MA;Olson,MS
通讯作者:
Olson,MS
影响因子:
4.4
作者:
M. Elstad;T. R. L. Pine;F. Cowley;R. McEver;T. McIntyre;S. Prescott;G. Zimmerman
通讯作者:
M. Elstad;T. R. L. Pine;F. Cowley;R. McEver;T. McIntyre;S. Prescott;G. Zimmerman
影响因子:
15.9
作者:
LORANT,DE;TOPHAM,MK;ZIMMERMAN,GA
通讯作者:
ZIMMERMAN,GA
DOI:
--
发表时间:
1992
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Patel,KD;Zimmerman,GA;Prescott,SM;McIntyre,TM
通讯作者:
McIntyre,TM