SUBSTANTIA NIGRA OF RAT - GOLGI STUDY
SUBSTANTIA NIGRA OF RAT - GOLGI STUDY
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DOI：
10.1002/cne.901720403
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发表时间：
1977-01-01
影响因子：
2.5
通讯作者：
GROVES, PM
中科院分区：
文献类型：
--
作者：
JURASKA, JM;WILSON, CJ;GROVES, PM
用高尔基体法的三种变异体，观察了白化大鼠和白帽大鼠黑质内的细胞类型、树突域及其组织和轴突轨迹。在矢状面和冠状切面上，根据胞体大小、树突野范围和树突口径对大、中、小神经元进行分类。黑质细胞有3-5个较少分支的初级树突。所有细胞类型的一些树突都有稀疏散布的刺或曲张。小细胞分布于细胞核的所有区域，具有细小的树突和小的、非定向的树突场。这些可能是中间神经元。在致密部发现的中间细胞，被认为是黑质纹状体通路的多巴胺能细胞，向网状部发出长长的树突，与致密部的走向垂直。这些细胞有许多留在致密部的树突。这些细胞的轴突位于背部中段。未检测到轴突侧支。网状部既有大细胞，也有中等细胞。网状部背内侧的细胞大致垂直于致密部的走行走向，而脚周区的细胞则呈严格的平行于大脑小脚的方向。一些网状部细胞发出轴突侧支，而另一些细胞在可观察到的长度内保持不分支。在外侧部也可见大细胞和中等细胞。这些细胞将较长的树突送入网状部，在那里它们与大脑脚平行，而一些较短的树突留在外侧部内。黑质似乎具有分层结构：上层为细胞部致密部，第2层为网状部背内侧，致密部和网状部树突均分布于吻尾和背腹侧，第3层为脚周区，所有区域的树突均与大脑脚平行。
Three variants of the Golgi method were employed to examine the cell types, their dendritic fields and organization and axonal trajectories within the substantia nigra of albino and hooded rats. In both sagittal and coronal sections, large, medium and small neurons were classified on the basis of soma size, extent of dendritic fields and dendritic caliber. Nigral cells have 3-5 primary dendrites that branch relatively infrequently. Some dendrites of all cell types have thinly scattered spines or varicosities. Small cells, found in all areas of the nucleus, have thin dendrites and small, non-directional dendritic fields. These may be interneurons. The medium cells found in pars compacta, presumed to be the dopaminergic cells of the nigroneostriatal pathway, send long dendrites into pars reticulata perpendicular to the course of pars compacta. These cells have a number of dendrites which remain in pars compacta. These cells have axons that run medio-dorsally. No axon collaterals were detected. Both large and medium cells are found in pars reticulata. Cells in the dorso-medial aspect of pars reticulata orient rostro-caudally and roughly perpendicular to the course of pars compacta, while cells in the peripeduncular area show a strict orientation which is parallel to the crus cerebri. Some pars reticulata cells emit axon collaterals while others remain unbranched for their observable length. Both large and medium cells are also seen in pars lateralis. These cells send long dendrites ventrally into pars reticulata where they run parallel to the crus cerebri, while some shorter dendrites remain in pars lateralis. The substantia nigra appears to have a layered organization: the superior layer is the cellular pars compacta, the 2nd is the dorso-medial area of pars reticulata where both pars compacta and pars reticulata dendrites run rostro-caudally and dorso-ventrally and the 3rd layer is the peripeduncular region where dendrites from all areas run parallel to the crus cerebri.