A Novel Noninvasive Method for Quantitative Detection of Colonic Dysmotility Using Real-Time Ultrasonography
A Novel Noninvasive Method for Quantitative Detection of Colonic Dysmotility Using Real-Time Ultrasonography
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DOI：
10.1159/000511851
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发表时间：
2020-12
期刊：
影响因子：
3.2
通讯作者：
Kazuhisa Kishi;N. Kaji;Yoshiharu Tsuru;M. Hori
中科院分区：
文献类型：
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作者：
Kazuhisa Kishi;N. Kaji;Yoshiharu Tsuru;M. Hori
简介：结肠动力障碍是由各种药物和疾病引起的常见临床问题。然而，由于缺乏体内方法，包括快速动态评估，结肠动力障碍的病因往往不清楚。目的：本研究的目的是建立一种新的定量方法，利用超声检查客观评估结肠运动。方法：我们应用基于超声心动图斑点追踪的应变成像来分析小鼠结肠运动。在结肠近端壁与内腔之间的边界处放置迹线以分析结肠壁位移和应变率。结肠壁的运动活动用于通过超声检查量化结肠运动。结果：我们发现超声检查可以定量检测止泻药洛哌丁胺引起的结肠运动减少。这些定量数据与结肠蠕动和结肠传输时间的成像结果一致。此外，超声检查还显示短时间间隔内结肠运动的变化。此外，我们还表明，超声检查可以定量、无创地检测结肠炎小鼠的结肠运动障碍和结肠壁血管丰富性。结论：这些研究结果表明，超声检查是客观监测药物和疾病引起的结肠运动变化的一种有用的体内方法。
Introduction: Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. Objectives: The aim of this study was to establish a novel quantitative method to objectively assess colonic motility using ultrasonography. Methods: We applied echocardiographic speckle tracking-based strain imaging to analyze murine colonic motility. A trace line was placed on the boundary between the proximal wall of the colon and the inner cavity to analyze colonic wall displacement and strain rate. Locomotion activities of the colonic wall were used to quantify colonic motility via ultrasonography. Results: We found that ultrasonography can quantitatively detect a decrease in colonic motility induced by loperamide, an antidiarrheal drug. These quantitative data were consistent with the imaging findings of colonic peristalsis and colon transit time. Additionally, ultrasonography also revealed changes in colonic motility over short intervals. Furthermore, we have shown that ultrasonography can quantitatively and noninvasively detect colonic dysmotility and hypervascularity of the colonic wall in colitis mice. Conclusions: These findings suggest that ultrasonography is a useful in vivo method for objectively monitoring changes in colonic motility caused by drugs and diseases.