Higher Numbers of Pregnancies Associated With an Increased Prevalence of Gestational Diabetes Mellitus: Results From the Healthy Baby Cohort Study
Higher Numbers of Pregnancies Associated With an Increased Prevalence of Gestational Diabetes Mellitus: Results From the Healthy Baby Cohort Study
复制标题
怀孕次数增多与妊娠期糖尿病患病率增加相关：健康婴儿队列研究的结果
DOI：
10.2188/jea.je20180245
复制
发表时间：
2020-05-01
影响因子：
4.7
通讯作者：
Wang, Youjie
中科院分区：
文献类型：
--
作者：
Liu, Bingqing;Song, Lulu;Wang, Youjie
背景怀孕会导致母体代谢和生活方式的重大改变。然而，反复暴露在这些变化中是否会影响妊娠期糖尿病(GDM)的发展仍不清楚。在本研究中，我们旨在调查中国女性怀孕次数与妊娠期糖尿病之间的关系。方法来自健康婴儿队列研究的7,008名受试者被纳入本研究。怀孕的数量被分为三类：1、2或≥3。妊娠期糖尿病是根据国际糖尿病协会和妊娠研究小组的标准诊断的。采用多因素Logistic回归模型。结果在完全调整的模型中，妊娠≥3的妇女患妊娠期糖尿病的风险增加了1.2 7倍(95%可信区间为1.0 5~1.5 4)。在30岁的≥妇女中，怀孕2次和3次的孕妇患妊娠期糖尿病的风险较高(OR分别为1.32；95%CI，1.01~1.73和1.54；95%CI，1.17~2.01)。在孕前体重指数为24公斤/平方米的妇女中，≥3级妊娠与妊娠期糖尿病风险增加1.35倍(95%可信区间，1.09-1.67)。结论妊娠次数多是妊娠期糖尿病的独立危险因素。怀孕次数和妊娠期糖尿病之间的关联在≥为30岁或孕前体重指数为24公斤/平方米的妇女中更为显著。
Background Pregnancy leads to substantial maternal metabolic and lifestyle alterations. However, it is still unclear whether repeated exposure to these changes will influence the development of gestational diabetes mellitus (GDM). In the present study, we aimed to investigate the association between the number of pregnancies and GDM among Chinese women. Methods A total of 7,008 subjects from the Healthy Baby Cohort study were included in this study. The number of pregnancies was classified into three categories: 1, 2, or ≥3 pregnancies. GDM was diagnosed using International Association of Diabetes and Pregnancy Study Groups criteria. Multivariate logistic regression models were used. Results In the fully adjusted model, women with ≥3 pregnancies had a 1.27-fold (95% confidence interval [CI], 1.05–1.54) higher risk of GDM. Among women ≥30 years old, 2 and ≥3 pregnancies were associated with a higher risk of GDM (odds ratio [OR] 1.32; 95% CI, 1.01–1.73 and OR 1.54; 95% CI, 1.17–2.01, respectively). Among women with a pre-pregnancy BMI <24 kg/m2, ≥3 pregnancies were associated with a 1.35-fold (95% CI, 1.09–1.67) higher risk of GDM. Conclusions Our findings suggested that higher numbers of pregnancies is an independent risk factor of GDM. The association between number of pregnancies and GDM was more prominent among women who were ≥30 years old or with a pre-pregnancy BMI <24 kg/m2.