Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes
Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes
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DOI：
10.1016/j.metabol.2016.12.018
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发表时间：
2017-07-01
影响因子：
9.8
通讯作者：
Holmang, Agneta
中科院分区：
文献类型：
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作者：
Chorell, Elin;Hall, Ulrika Andersson;Holmang, Agneta
语境。妊娠糖尿病通常与 2 型糖尿病 (T2DM) 的发展有关。需要表征与妊娠糖尿病相关的代谢变化，以便找到 T2DM 的新生物标志物。目的。通过研究从妊娠到产后的代谢转变，寻找从妊娠糖尿病进展为 T2DM 的潜在病理生理机制和标志物。设计。通过基于质谱的代谢组学对 56 名女性从怀孕到产后的代谢转变特征进行了表征； 11 名女性患有妊娠期糖尿病，24 名女性糖耐量正常，21 名女性血糖正常但患妊娠期糖尿病的风险增加。在诊断特异性多变量模型（正交偏最小二乘分析）中比较在妊娠第 3 个月（妊娠周 32 +/- 0.6）和产后（10.5 +/- 0.4 个月）收集的空腹血清样本。比较临床测量值（例如胰岛素、葡萄糖、血脂水平），并计算同一时间段的胰岛素敏感性和抵抗性模型。结果。患有妊娠糖尿病的女性产后支链氨基酸（BCAA）亮氨酸、异亮氨酸和缬氨酸的水平显着升高，并且她们的循环血脂在怀孕后并未恢复到正常水平。支链氨基酸的增加发生在产后，因为与血糖正常的女性相比，支链氨基酸在怀孕期间没有差异。结论。产后特定支链氨基酸（尤其是缬氨酸）的水平与怀孕期间的妊娠糖尿病有关。 (C) 2017 Elsevier Inc. 保留所有权利。
Context. Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM.Objective. To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum.Design. The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 +/- 0.6) and postpartum (10.5 +/- 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period.Results. Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women.Conclusions. Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy. (C) 2017 Elsevier Inc. All rights reserved.