CONTRIBUTION OF VISCERAL FAT MASS TO THE INSULIN-RESISTANCE OF AGING
CONTRIBUTION OF VISCERAL FAT MASS TO THE INSULIN-RESISTANCE OF AGING
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DOI：
10.1016/0026-0495(95)90251-1
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发表时间：
1995-07-01
影响因子：
9.8
通讯作者：
ANDERSON, R
中科院分区：
文献类型：
--
作者：
CEFALU, WT;WANG, ZQ;ANDERSON, R
最近的研究表明，中心性肥胖（腰臀比[WHR]增加）与胰岛素抵抗和衰老有关。此外，在中心性肥胖状态下，腹腔内脂肪（IAF）贮库被认为是胰岛素抵抗发展的主要原因。因此，观察到的胰岛素抵抗的老化可能更多地与身体组成的变化，而不是老化本身。本研究的目的是探讨IAF与年龄和控制肥胖后的胰岛素敏感性（S-I）的关系。我们检查了60名健康非糖尿病受试者（75克口服葡萄糖耐量试验正常，年龄23至83岁，其中15名男性和45名女性）。我们选择的受试者，使那些小于或等于125%和大于125%的理想体重在每个年龄段的代表性相等。我们使用经验证的磁共振成像（MRI）扫描技术量化了脐部的总腹部脂肪和皮下脂肪以及IAF，并使用改良的最小模型确定了S-I。IAF与年龄显著相关（r = 0.49，P = 0.0001），男性（r = 0.58，P = 0.022）和女性（r = 0.48，P = 0.0008）也是如此。在所有受试者中，S-I与IAF显著相关（r =-0.50，P <0.0001），但与年龄无关（r = 0.00，P = 0.98）。在对年龄、性别和脂肪分布测量的各种组合的多变量分析中，WHR占S-I方差的28%，IAF占51%，而年龄、性别以及年龄和性别的相互作用仅占1%。总之，IAF质量被认为是脂肪库中代谢最活跃的，它与健康的非糖尿病个体的胰岛素抵抗和年龄显著相关，无论性别如何，并且在控制肥胖之后。桑德斯公司
Recent studies have shown that central obesity (increased waist to hip ratio [WHR]) is related to insulin resistance and aging. Furthermore, in central obesity states, the intraabdominal fat (IAF) depot has been postulated to contribute most to the development of insulin resistance. Therefore, the observed insulin resistance of aging may be related more to changes in body composition than to aging per se. The purpose of this study was to explore the association of IAF with age and insulin sensitivity (S-I) after controlling for obesity. We examined 60 healthy nondiabetic subjects (normal 75-g oral glucose tolerance test, aged 23 to 83, 15 men and 45 women). We chose subjects so that those less than or equal to 125% and greater than 125% of ideal body weight were equally represented in each age decade. We quantified total and subcutaneous abdominal fat and IAF at the umbilicus using a validated magnetic resonance imaging (MRI) scanning technique and determined S-I using a modified minimal model. IAF correlated significantly with age (r = .49, P = .0001) in the group as a whole, as well as in men (r = .58, P = .022) and women (r = .48, P = .0008) separately. In all subjects, S-I was significantly related to IAF (r = -.50, P < .0001) but was not related to age (r = .00, P = .98). In multivariate analysis for various combinations of age, sex, and measures of fat distribution, WHR accounted for 28% and IAF for 51% of the variance in S-I, whereas age, sex, and interactions of age and sex accounted for only 1%. In conclusion, IAF mass, which has been postulated to be the most metabolically active of the adipose depots, correlates significantly with insulin resistance and age in healthy nondiabetic individuals regardless of gender and after controlling for obesity.Copyright (C) 1995 by W.B. Saunders Company