Glaucoma filtering surgery with 5-fluorouracil.
Glaucoma filtering surgery with 5-fluorouracil.
复制标题
使用 5-氟尿嘧啶进行青光眼滤过手术。
DOI：
10.1016/s0161-6420(87)33321-4
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发表时间：
1987
期刊：
影响因子：
13.7
通讯作者：
Feuer,W
中科院分区：
文献类型：
--
作者：
Rockwood,EJ;Parrish2nd,RK;Heuer,DK;Skuta,GL;Hodapp,E;Palmberg,PF;Gressel,MG;Feuer,W
对 155 名患者的第一只眼睛进行了手术结果的生命表分析，这些患者参加了一项青光眼滤过手术术后结膜下注射 5-氟尿嘧啶 (5-FU) 的试点研究。对于 88 名患有无晶状体的非新生血管性青光眼患者，间隔 1 年、2 年和 3 年的成功率分别为 68%、63% 和 63%； 39 例滤过手术失败后患有非新生血管性青光眼的患者分别为 82%、75% 和 75%； 28 名新生血管性青光眼患者每年的死亡率为 68%。滤过手术和5-FU注射引起的并发症包括角膜上皮缺损（55.5%）、结膜伤口渗漏（36.8%）、脉络膜上腔出血（5.8%）、孔源性视网膜脱离（2.6%）、眼内炎和肺结核（各1.9%）、角膜疤痕、晚期滤泡渗漏、恶性青光眼和牵引视网膜脱离（各 1.3%）。 Cox 模型回归分析未能证明手术成功与年龄、种族、过滤手术类型或接受的 5-FU 总剂量之间的相关性。对于青光眼滤过性手术后失败风险较高的特定患者，术后结膜下 5-FU 可能会提高手术成功率。
A life-table analysis of surgical outcomes was performed on the first eye of 155 patients who were enrolled in a pilot study of glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU) injections. The success rates at 1-, 2-, and 3-year intervals were 68, 63, and 63%, respectively, for 88 patients with non-neovascular glaucoma in aphakia; 82, 75, and 75% for 39 patients with non-neovascular glaucoma after unsuccessful filtering surgery; and 68% at each yearly interval for 28 patients with neovascular glaucoma. Complications which resulted from filtering surgery and the 5-FU injections included corneal epithelial defects (55.5%), conjunctival wound leaks (36.8%), suprachoroidal hemorrhage (5.8%), rhegmatogenous retinal detachment (2.6%), endophthalmitis and phthisis (1.9% each), and corneal scarring, late bleb leak, malignant glaucoma, and traction retinal detachment (1.3% each). A Cox Model regression analysis failed to demonstrate a correlation between surgical success and age, race, type of filtering procedure, or total dose of 5-FU received. Postoperative subconjunctival 5-FU may increase the operative success rate for selected patients with a high risk for failure after glaucoma filtering surgery.