Increased infection with key periodontal pathogens during gestational diabetes mellitus.
Increased infection with key periodontal pathogens during gestational diabetes mellitus.
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DOI：
10.1111/jcpe.12418
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发表时间：
2015-06
影响因子：
6.7
通讯作者：
Özçaka Ö
中科院分区：
文献类型：
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作者：
Gogeneni H;Buduneli N;Ceyhan-Öztürk B;Gümüş P;Akcali A;Zeller I;Renaud DE;Scott DA;Özçaka Ö
妊娠期糖尿病（GDM）、牙龈炎、特定牙周病原体感染和全身性炎症都会增加妊娠结局不佳的风险。我们开始监测牙龈炎和GDM在口腔感染和全身炎症负担方面的相互作用。招募4个病例对照组（n = 117），(1)无牙龈炎，无GDM (n = 27)；(2)牙龈炎，无GDM（31例）；(3)无牙龈炎、GDM (n = 21)；(4)牙龈炎，GDM （n = 38）。采用聚合酶链反应（PCR）检测口腔3种主要牙周病原菌的感染情况。采用EIA定量CRP测定全身性炎症。妊娠期牙龈炎与口腔感染牙龈卟啉单胞菌、白化丝状因子、密螺旋体及其组合相关（p < 0.01）。GDM还与个体和多种口腔病原体感染增加相关（均p < 0.05）。妊娠期牙龈炎导致全身CRP升高325%（平均2495对8116 ng/ml， p < 0.01）。糖尿病和牙龈炎共同增加不良妊娠结局的生物标志物风险。
Gestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. Four case–control groups (n = 117) were recruited, (1) No gingivitis, No GDM (n = 27); (2) Gingivitis, No GDM (n = 31); (3) No gingivitis, GDM (n = 21); and (4) Gingivitis, GDM (n = 38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA. Gingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p < 0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p < 0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116 ng/ml, p < 0.01). Diabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.