A New Measure of Movement Symmetry in Early Parkinson's Disease Patients Using Symbolic Processing of Inertial Sensor Data
A New Measure of Movement Symmetry in Early Parkinson's Disease Patients Using Symbolic Processing of Inertial Sensor Data
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DOI：
10.1109/tbme.2011.2149521
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发表时间：
2011-07-01
影响因子：
4.6
通讯作者：
Wickstrom, Nicholas
中科院分区：
文献类型：
--
作者：
Sant'Anna, Anita;Salarian, Arash;Wickstrom, Nicholas
运动不对称是与帕金森病（PD）相关的运动症状之一。因此，能够检测和测量运动对称性对于监测患者的状况是重要的。本文介绍了一种新的基于符号的对称性指数计算的惯性传感器数据。该方法的解释，评估，并与其他六个对称措施。这些措施被用来确定对称的上肢和下肢在步行过程中的11个早期到中期的PD患者和15个对照组。根据统一的帕金森病评定量表（UNITED Parkinson's disease rating scale，简称PDRS），纳入研究的患者表现出最小的运动异常。使用对称性指数将受试者分为两组，分别对应于PD组和对照组。该方法具有较高的灵敏度和特异性，受试者工作特征（ROC）曲线下面积为0.872，比第二好的方法大9%。所提出的方法还显示出0.949的优异的组内相关系数（ICC），比第二好的方法大55%。结果表明，建议的对称指数是适当的，这一特定群体的患者。
Movement asymmetry is one of the motor symptoms associated with Parkinson's disease (PD). Therefore, being able to detect and measure movement symmetry is important for monitoring the patient's condition. The present paper introduces a novel symbol based symmetry index calculated from inertial sensor data. The method is explained, evaluated, and compared to six other symmetry measures. These measures were used to determine the symmetry of both upper and lower limbs during walking of 11 early-to-mid-stage PD patients and 15 control subjects. The patients included in the study showed minimal motor abnormalities according to the unified Parkinson's disease rating scale (UPDRS). The symmetry indices were used to classify subjects into two different groups corresponding to PD or control. The proposed method presented high sensitivity and specificity with an area under the receiver operating characteristic (ROC) curve of 0.872, 9% greater than the second best method. The proposed method also showed an excellent intraclass correlation coefficient (ICC) of 0.949, 55% greater than the second best method. Results suggest that the proposed symmetry index is appropriate for this particular group of patients.