Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality.
Screening of Oral Potentially Malignant Disorders Using Exfoliative Cytology: A Diagnostic Modality.
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DOI：
10.1155/2016/8134832
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发表时间：
2016
影响因子：
1.8
通讯作者：
Chatterjee K
中科院分区：
文献类型：
--
作者：
Kabiraj A;Khaitan T;Bhowmick D;Ginjupally U;Bir A;Chatterjee K
目标。口腔剥脱细胞学（OEC）在病理病变的诊断中已经应用了很长时间。本研究旨在通过简单的程序评估一些最常见的潜在恶性疾病（白斑、扁平苔藓和口腔粘膜下纤维化）的细胞形态学特征，并说明其在大规模筛查中的重要性。材料和方法。本研究共纳入了160名年龄在25-50岁之间的受试者。其中临床诊断为口腔白斑40例，诊断为口腔扁平苔藓40例，诊断为口腔黏膜下纤维化40例，对照组40例。制备的涂片经Papanicolaou染色，显微镜下分析细胞形态学特征。结果和讨论。显微镜下分析，40例口腔白斑病变中36例（90%）表现为II级细胞学特征，而4例（10%）表现为I级特征。40例口腔扁平苔藓患者中，有26例（65%）表现为II类特征，其余14例（35%）表现为I类特征。在40例口腔黏膜下纤维化患者中，32例（80%）表现为II类特征，8例（20%）表现为I类特征。40名对照者均表现为I类特征。因此，OEC可以被广泛提倡作为临床结论的补充和活检的辅助。
Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening. Materials and Method. A total of 160 subjects with 25–50 years of age were included in the study. Among them, 40 were clinically diagnosed with oral leukoplakia, 40 were diagnosed with oral lichen planus, 40 were diagnosed with oral submucous fibrosis, and 40 were in the control group. The prepared smears were subjected to Papanicolaou stain and analyzed microscopically for the evaluation of the cytomorphological features. Results and Discussion. When analyzed microscopically, 36 (90%) out of the 40 oral leukoplakic lesions showed Class II cytological features whereas 4 (10%) revealed Class I features. Among 40 patients with oral lichen planus, 26 (65%) showed Class II features while the remaining 14 (35%) revealed Class I features. In 40 subjects with oral submucous fibrosis, 32 (80%) showed Class II features while the other 8 (20%) showed Class I features. All the 40 control subjects showed Class I features. Thus, OEC can be widely advocated as an addition to clinical conclusion and an adjunct to biopsy.