Contribution of the histone variant H2A.Z to expression of responsive genes in plants.
Contribution of the histone variant H2A.Z to expression of responsive genes in plants.
复制标题
组蛋白变体 H2A.Z 对植物中响应基因表达的贡献。
DOI：
10.1016/j.semcdb.2022.04.006
复制
发表时间：
2023
影响因子：
7.3
通讯作者：
Ogas,Joe
中科院分区：
文献类型：
--
作者：
Long,Jiaxin;Carter,Benjamin;Johnson,EmilyT;Ogas,Joe
组蛋白变体H2A. Z在真核生物中基于染色质的过程如转录、复制和修复中起关键作用。尽管许多H2A. Z相关的过程和特征在植物和动物中是保守的，但植物染色质的一个显著特征是H2A. Z在表现出动态表达的基因体中的富集，特别是响应于分化和环境。最近的工作揭示了新的光的植物机制，使动态变化的H2A.Z富集，并确定额外的染色质为基础的途径，有助于转录特性的H2A.Z富集的染色质。特别是，多种响应基因座的分析揭示了H2A.Z在响应基因表达中的抑制作用，并鉴定了SWR1和INO80染色质重塑物在实现H2A.Z水平和转录的动态调节中的作用。这些研究为理解这种古老的组蛋白变体如何被植物利用以实现响应性和动态的基因表达奠定了基础。
The histone variant H2A.Z plays a critical role in chromatin-based processes such as transcription, replication, and repair in eukaryotes. Although many H2A.Z-associated processes and features are conserved in plants and animals, a distinguishing feature of plant chromatin is the enrichment of H2A.Z in the bodies of genes that exhibit dynamic expression, particularly in response to differentiation and the environment. Recent work sheds new light on the plant machinery that enables dynamic changes in H2A.Z enrichment and identifies additional chromatin-based pathways that contribute to transcriptional properties of H2A.Z-enriched chromatin. In particular, analysis of a variety of responsive loci reveals a repressive role for H2A.Z in expression of responsive genes and identifies roles for SWR1 and INO80 chromatin remodelers in enabling dynamic regulation of H2A.Z levels and transcription. These studies lay the groundwork for understanding how this ancient histone variant is harnessed by plants to enable responsive and dynamic gene expression (Graphical Abstract).