Interaction with membrane remnants of target myotubes maintains transmitter sensitivity of cultured neurons.
Interaction with membrane remnants of target myotubes maintains transmitter sensitivity of cultured neurons.
复制标题
与目标肌管的膜残余物的相互作用维持培养神经元的递质敏感性。
DOI：
10.1126/science.6133352
复制
发表时间：
1983
期刊：
影响因子：
56.9
通讯作者：
J. Tuttle
中科院分区：
文献类型：
--
作者：
J. Tuttle
Parasympathetic neurons, when cultured alone, lose sensitivity to acetylcholine, but if striated muscle is included in the culture, neuronal chemosensitivity is maintained. The membrane remnants of myotubes ruptured by osmotic shock also supported the responsiveness of the cultured neurons to transmitter, whereas muscle-conditioned medium or membrane remnants of nonmuscle embryonic skin cells did not support this responsiveness. The regulation of chemosensitivity by contact of neurons with the target cell membrane may be important in the formation and maintenance of neuronal circuitry.
