Diagnostic and prognostic value of serum MACC1 in breast cancer patients.
Diagnostic and prognostic value of serum MACC1 in breast cancer patients.
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血清 MACC1 对乳腺癌患者的诊断和预后价值。
DOI：
10.18632/oncotarget.12910
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发表时间：
2016-12-20
期刊：
影响因子：
--
通讯作者：
Zheng W
中科院分区：
文献类型：
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作者：
Tan W;Xie X;Li L;Tang H;Ye X;Chen L;Tang W;Gao J;Pan L;Zhang X;Ye F;Li X;Yang L;Xie X;Zheng W
结肠癌转移相关-1 (MACC1) 可促进结直肠癌进展并预测预后。我们研究的目的是确定乳腺癌患者术前血清 MACC1 水平的诊断和预后价值。使用 ELISA 测量了 378 名乳腺癌患者、120 名良性乳腺疾病患者和 40 名健康志愿者的血清 MACC1 水平。乳腺癌患者的血清 MACC1 水平高于良性疾病患者或健康志愿者。血清 MACC1 升高与乳腺癌 TNM 分期 (P < 0.001)、肿瘤大小 (P < 0.001)、淋巴结转移 (P < 0.001) 和 Ki-67 状态 (P = 0.014) 相关。血清 MACC1 测量成功区分乳腺癌患者与正常和健康对照（AUC = 0.785，95% CI：0.746–0.825），最佳截止值为 38.35 pg/ml（敏感性 = 0.725，特异性 = 0.696）。此外，血清MACC1在乳腺癌中表现出显着的预后价值（AUC = 0.757，95% CI：0.700–0.814），高MACC1与较差的无病生存率相关（HR 5.63，95% CI：3.51–9.04；P < 0.001）。我们的研究结果表明，循环 MACC1 可以作为乳腺癌可靠的诊断和预后生物标志物。
Metastasis-associated in colon cancer-1 (MACC1) promotes colorectal cancer progression and predicts prognosis. The aim of our study was to determine the diagnostic and prognostic value of preoperative serum MACC1 levels in breast cancer patients. Serum MACC1 levels were measured in 378 breast cancer patients, 120 patients with benign breast disease, and 40 healthy volunteers using an ELISA. Serum MACC1 levels were higher in breast cancer patients than patients with benign disease or healthy volunteers. Increased serum MACC1 was associated with breast cancer TNM stage (P < 0.001), tumor size (P < 0.001), lymph node metastasis (P < 0.001), and Ki-67 status (P = 0.014). Serum MACC1 measurement successfully discriminated breast cancer patients from normal and healthy controls (AUC = 0.785, 95% CI: 0.746–0.825) with an optimal cut-off value of 38.35 pg/ml (sensitivity = 0.725, specificity = 0.696). Moreover, serum MACC1 exhibited significant prognostic value in breast cancer (AUC = 0.757, 95% CI: 0.700–0.814), and high MACC1 was associated with poor disease-free survival (HR 5.63, 95% CI: 3.51–9.04; P < 0.001). Our findings demonstrated that circulating MACC1 could serve as a reliable diagnostic and prognostic biomarker for breast cancer.