State dependence of noise correlations in macaque primary visual cortex.
State dependence of noise correlations in macaque primary visual cortex.
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DOI：
10.1016/j.neuron.2014.02.006
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发表时间：
2014-04-02
期刊：
影响因子：
16.2
通讯作者：
Tolias AS
中科院分区：
文献类型：
--
作者：
Ecker AS;Berens P;Cotton RJ;Subramaniyan M;Denfield GH;Cadwell CR;Smirnakis SM;Bethge M;Tolias AS
神经元种群中共享的试验性变异性对大脑信息处理的准确性有很大的影响。这些差异在这里解决了一个重要的因素，该因素在整个研究中都不同，询问麻醉如何影响猕猴的主要视觉皮层。麻醉，活动在1-2 Hz的时间尺度上强烈协调的波动，这些波动大多在清醒中没有，固定猴子。麻醉和清醒的动物。我们的结果表明，内部信号（例如大脑状态过渡相关性，但也可以根据神经元种群活动来估算和考虑。
Shared, trial-to-trial variability in neuronal populations has a strong impact on the accuracy of information processing in the brain. Estimates of the level of such noise correlations are diverse, ranging from 0.01 to 0.4, with little consensus on which factors account for these differences. Here we addressed one important factor that varied across studies, asking how anesthesia affects the population activity structure in macaque primary visual cortex. We found that under opioid anesthesia, activity was dominated by strong coordinated fluctuations on a timescale of 1–2 Hz, which were mostly absent in awake, fixating monkeys. Accounting for these global fluctuations markedly reduced correlations under anesthesia, matching those observed during wakefulness and reconciling earlier studies conducted under anesthesia and in awake animals. Our results show that internal signals, such as brain state transitions under anesthesia, can induce noise correlations, but can also be estimated and accounted for based on neuronal population activity.
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