Intravascular Ultrasound (IVUS): A Potential Arthroscopic Tool for Quantitative Assessment of Articular Cartilage.
Intravascular Ultrasound (IVUS): A Potential Arthroscopic Tool for Quantitative Assessment of Articular Cartilage.
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DOI：
10.2174/1874120700903010013
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发表时间：
2009-06-26
期刊：
影响因子：
--
通讯作者：
Zheng YP
中科院分区：
文献类型：
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作者：
Huang YP;Zheng YP
传统的关节软骨超声检查在关节周围的身体表面上进行外部的准确性有限，由于使用的频率不足。与此相反，具有足够高频率的微创关节镜超声可能是评估软骨的更好选择。到目前为止，还没有设计出在关节镜下使用的用于软骨成像的特殊超声换能器。在这项研究中，我们介绍了血管内超声（IVUS）为此目的。应用血管内超声（IVUS）系统和探头（直径1mm）对体外培养的牛髌关节软骨在酶处理诱导退变前后的厚度和表面声反射进行了测量。使用另一种具有更大尺寸探头的高频超声系统（Vevo）进行类似的测量，并将两种系统的结果进行比较。IVUS测量的厚度与Vevo测量的厚度高度相关（r = 0.985，p < 0.001）。使用IVUS在酶消化的关节软骨上测量的厚度和表面反射幅度显示出与Vevo获得的变化相似的变化，这与以前的研究结果基本一致。IVUS具有即用型关节镜特征，可用于关节软骨的定量评估。
Conventional ultrasound examination of the articular cartilage performed externally on the body surface around the joint has limited accuracy due to the inadequacy in frequency used. In contrast to this, minimally invasive arthroscopy-based ultrasound with adequately high frequency may be a better alternative to assess the cartilage. Up to date, no special ultrasound transducer for imaging the cartilage in arthroscopic use has been designed. In this study, we introduced the intravascular ultrasound (IVUS) for this purpose. An IVUS system with a catheter-based probe (Ø ≈ 1mm) was used to measure the thickness and surface acoustical reflection of the bovine patellar articular cartilage in vitro before and after degeneration induced by enzyme treatments. Similar measurement was performed using another high frequency ultrasound system (Vevo) with a probe of much larger size and the results were compared between the two systems. The thickness measured using IVUS was highly correlated (r = 0.985, p < 0.001) with that obtained by Vevo. Thickness and surface reflection amplitude measured using IVUS on the enzymatically digested articular cartilage showed changes similar to those obtained by Vevo, which were expectedly consistent with previous investigations. IVUS can be potentially used for the quantitative assessment of articular cartilage, with its ready-to-use arthroscopic feature.