Altered structural connectivity and cytokine levels in Schizophrenia and Genetic high-risk individuals: Associations with disease states and vulnerability.
Altered structural connectivity and cytokine levels in Schizophrenia and Genetic high-risk individuals: Associations with disease states and vulnerability.
复制标题
精神分裂症和遗传高危个体的结构连接和细胞因子水平改变：与疾病状态和脆弱性的关联。
DOI：
10.1016/j.schres.2020.05.044
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发表时间：
2020
影响因子：
4.5
通讯作者：
Wang,Fei
中科院分区：
文献类型：
--
作者：
Wang,Yang;Wei,Yange;Edmiston,EKale;Womer,FayY;Zhang,Xizhe;Duan,Jia;Zhu,Yue;Zhang,Ran;Yin,Zhiyang;Zhang,Yifan;Jiang,Xiaowei;Wei,Shengnan;Liu,Zhuang;Zhang,Yanbo;Tang,Yanqing;Wang,Fei
背景在精神分裂症（SZ）和SZ遗传高危个体（GHR-SZ）中均观察到白色物质（WM）完整性的改变，然而，WM破坏的分子机制尚不清楚。细胞因子是免疫系统的化学信使，与大脑中的炎症和神经发生密切相关。本研究的目的是确定异常WM的完整性，细胞因子水平，并在SZ和GHR-SZ.MethodsA共355名参与者（126 SZ，99 GHR-SZ，和130名健康对照[HC]）被招募。结果在SZ，胼胝体的前部和体部（GCC/BCC）、前放射冠、内囊的前、后肢的各向异性分数（FA）降低（ALIC/PLIC）、上级额枕束、外囊和穹窿，以及升高的IL-6水平。在SZ和GHR-SZ中，观察到胼胝体压部（SCC）、后放射冠（PCR）和后丘脑放射（PTR）的FA降低，瘦素水平升高。此外，IL-6水平呈负相关，FA在GCC和ALIC在SZ，瘦素水平呈负相关，SCC，PCR和PTR在SZ和GHR-SZ。结论异常WM完整性SZ可能反映了疾病的状态，并与IL-6水平升高。此外，这些瘦素相关的WM的完整性异常，在SZ和GHR-SZ可能反映了遗传易感性SZ。
BackgroundAlterations of white matter (WM) integrity have been observed in both schizophrenia (SZ) and individuals at genetic high risk for SZ (GHR-SZ); however, the molecular mechanisms underlying WM disruption remain unclear. Cytokines are chemical messengers of the immune system that are closely related to inflammation and neurogenesis in the brain. This study aimed to identify abnormalities in WM integrity, cytokine levels, and their association in SZ and GHR-SZ.MethodsA total of 355 participants (126 with SZ, 99 GHR-SZ, and 130 healthy controls [HCs]) were recruited. All participants underwent diffusion tensor imaging and blood samples were obtained from 113 participants within 24 h of imaging.ResultsIn SZ, there was decreased fractional anisotropy(FA) in the genu and body of the corpus callosum (GCC/BCC), anterior corona radiata, anterior and posterior limbs of the internal capsule (ALIC/PLIC), superior fronto-occipital fasciculus, external capsule, and fornix, and elevated IL-6 levels. In both SZ and GHR-SZ, decreased FA in the splenium of the corpus callosum (SCC), posterior corona radiate (PCR), and posterior thalamic radiation (PTR) was observed, and elevated leptin levels were present. Additionally, the IL-6 levels were negatively correlated with FA in the GCC and ALIC in SZ, and leptin levels were negatively correlated with the SCC, PCR, and PTR in SZ and GHR-SZ.ConclusionsAbnormal WM integrity in SZ may reflect the state of disease and is associated with increased IL-6 levels. In addition, these leptin-associated WM integrity abnormalities in both SZ and GHR-SZ may reflect a genetic vulnerability to SZ.