Malignant phyllodes tumor of the prostate: Retrospective review of specimens obtained by sequential transurethral resection
Malignant phyllodes tumor of the prostate: Retrospective review of specimens obtained by sequential transurethral resection
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DOI：
10.1046/j.1440-1827.2002.01417.x
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发表时间：
2002-12-01
影响因子：
2.2
通讯作者：
Shiraishi, T
中科院分区：
文献类型：
--
作者：
Watanabe, M;Yamada, Y;Shiraishi, T
本文报告一位67岁男性前列腺恶性叶状瘤的病例。病人因尿潴留被转送到医院。从三次经尿道前列腺切除术（TURP）的材料中，组织学诊断为良性前列腺增生。然而，在第四次TURP时，由于存在细长的上皮管和增殖的细胞间质并有丝分裂和核异型性，诊断为叶状瘤。2个月后行全膀胱前列腺切除术。组织学上，肿瘤由发育不良的间质细胞和不规则伸长的上皮管组成。5个月后，患者出现多发肺及盆腔淋巴结转移并死亡。本报告记录了前列腺叶状瘤的进展到更高的组织学级别，并记录了4例TURP和手术标本的顺序病理结果，时间约为3年。
A case of malignant phyllodes tumor of the prostate in a 67-year-old man is reported. The patient was referred to a hospital for urinary retention. From material taken at three transurethral resections of the prostate (TURP), a histological diagnosis of benign prostatic hyperplasia was made. However, at the fourth TURP, phyllodes tumor was diagnosed due to the presence of elongated epithelial ducts and proliferating cellular stroma with mitosis and nuclear atypia. Two months later, total cystoprostatectomy was performed. Histologically, the tumor was composed of dysplastic stromal cells and irregularly elongated epithelial ducts. Five months later the patient developed multiple lung and pelvic lymph node metastases and died. This report documents progression to a higher histological grade of prostatic phyllodes tumor documented with sequential pathological findings obtained from four TURP and surgical specimens over about 3 years.