HEPATOTOXICITY ASSOCIATED WITH CISPLATIN CHEMOTHERAPY
HEPATOTOXICITY ASSOCIATED WITH CISPLATIN CHEMOTHERAPY
复制标题
DOI：
10.1177/106002809302700408
复制
发表时间：
1993-04-01
影响因子：
2.9
通讯作者：
CERSOSIMO, RJ
中科院分区：
文献类型：
--
作者：
CERSOSIMO, RJ
目的：报告一例可能与顺铂相关的肝毒性病例。 病例摘要：一名 69 岁男性接受了 3 个周期的顺铂（100 mg/m2）和氟尿嘧啶（1000 mg/m2/d，共 5 天）治疗头颈部鳞状细胞癌。每个治疗周期前，肝酶浓度均在正常范围内，但天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶和乳酸脱氢酶浓度在每个周期的第二天增加。尽管继续给予氟尿嘧啶，但浓度在每个疗程的第3天开始下降，并在第10天恢复正常。患者的止吐治疗包括第1周期中的甲氧氯普胺和第2和第3周期中的昂丹司琼，这可能导致酶升高。讨论：回顾了顺铂相关肝毒性的病例报告。该患者的顺铂给药与肝毒性之间存在关联。结论：该患者可能经历了顺铂引起的肝损伤。甲氧氯普胺和昂丹司琼可能促成了这种效果。
OBJECTIVE: To report a case of possible cisplatin-associated hepatotoxicity.CASE SUMMARY: A 69-year-old man received three cycles of cisplatin (100 mg/m2) and fluorouracil (1000 mg/m2/d for five days) for management of squamous cell carcinoma of the head and neck. Liver enzyme concentrations were within normal limits prior to each cycle of therapy but the aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase concentrations increased on the second day of each cycle. The concentrations began to decline on day 3 of each course, despite continued fluorouracil administration, and returned to normal by day 10. The patient's antiemetic therapy included metoclopramide in cycle 1 and ondansetron in cycles 2 and 3, which may have contributed to the enzyme elevations.DISCUSSION: Case reports of cisplatin-associated hepatotoxicity are reviewed. An association between cisplatin administration and hepatotoxicity is proposed in this patient.CONCLUSIONS: This patient may have experienced cisplatin-induced liver damage. Metoclopramide and ondansetron may have contributed to this effect.