SEVERE HERPESVIRUS INFECTIONS IN AN ADOLESCENT WITHOUT NATURAL-KILLER CELLS
SEVERE HERPESVIRUS INFECTIONS IN AN ADOLESCENT WITHOUT NATURAL-KILLER CELLS
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DOI：
10.1056/nejm198906293202605
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发表时间：
1989-06-29
影响因子：
158.5
通讯作者：
SULLIVAN, JL
中科院分区：
文献类型：
--
作者：
BIRON, CA;BYRON, KS;SULLIVAN, JL
自然杀伤细胞是一群t细胞受体阴性（CD3 -）淋巴细胞，它们自发地介导敏感靶细胞的裂解。自然杀伤细胞在形态上与大颗粒淋巴细胞相似。1它们具有免疫球蛋白分子Fc部分的CD16受体2，它们在细胞表面表达补体受体-淋巴细胞粘附分子家族成员CD11b，3，以及决定因子NKH-1，这是大颗粒淋巴细胞所特有的。虽然从正常人身上分离的内源性杀伤细胞只能裂解有限范围内的高度敏感靶细胞，但干扰素和白细胞介素-2都能激活杀伤细胞裂解a细胞。
NATURAL killer cells are a population of T-cell–receptornegative (CD3–) lymphocytes that spontaneously mediate the lysis of sensitive target cells. Natural killer cells are similar morphologically to large granular lymphocytes.1They have the CD16 receptor for Fc portions of immunoglobulin molecules,2and they express a member of the complement receptor–lymphocyte adhesion family of molecules, CD11b,3on their cell surfaces, as well as the determinant NKH-1, which is specific to large granular lymphocytes.4Although endogenous killer cells isolated from normal persons lyse only a limited range of highly sensitive target cells, both interferon and interleukin-2 can activate killer cells to lyse a . . .