Alcohol drinking and colorectal cancer: A population-based prospective cohort study in China
Alcohol drinking and colorectal cancer: A population-based prospective cohort study in China
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DOI：
10.1007/s10654-004-2953-4
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发表时间：
2005-02-01
影响因子：
13.6
通讯作者：
Zheng, S
中科院分区：
文献类型：
--
作者：
Chen, K;Jiang, QT;Zheng, S
研究目的：评估中国人群中饮酒与结直肠癌（CRC）风险之间的关系。设计：以人群为基础的前瞻性队列研究，以嘉善县1989-1990年结直肠癌筛查人群为研究对象。个人的饮酒习惯进行了调查与人口统计学信息。设定：一项队列研究从1990年5月1日至2001年1月1日进行随访，并在诊断为CRC、任何原因导致的死亡或2001年1月1日（以先发生者为准）时删失，并计算人-时间。参与者：在研究期间诊断了242名CRC患者，64，100人完成了随访。结果如下：基线时不同饮酒习惯者的性别、吸烟状况、职业、文化程度和婚姻状况分布差异均有统计学意义。当调整上述因素后，饮酒与CRC风险之间没有显著相关性。排除在检查日期后不到1年内诊断为癌症的个体并没有改变酒精与CRC关系的强度。对性别分层的进一步分析也没有显示出显著的关系。结论：在中国人群中，饮酒可能与CRC的高风险无关。
Study objective: To asses the association between alcohol consumption and the risk of colorectal cancer (CRC) in the Chinese population. Design: A population-based prospective cohort study was initiated from the colorectal cancer screening population in Jiashan County in 1989-1990. The drinking habits of individuals were investigated with demographic information. Setting: A cohort study was followed-up from 1st May 1990 to 1st January 2001 and censored at the date of diagnosis of CRC, at death from any causes, or at 1st January 2001, whichever came first, and the person-time was computed. Participants: Two hundred and forty two CRC patients were diagnosed during the study period and 64,100 individuals finished the follow-up. Results: The distribution of sex, smoking status, occupation, education level and marital status were all significantly different among different drinking habits at baseline. When the above factors were adjusted, no significant association was observed between alcohol consumption and the risk of CRC. Exclusion of individuals diagnosed cancer less than 1 year after the examination date did not alter the strength of an alcohol-CRC relationship. Further analysis in sex strata also did not show a significant relationship. Conclusions: Alcohol drinking may not be associated with a higher risk of CRC in the Chinese population.