Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics.
Beyond Structure: Defining the Function of the Gut Using Omic Approaches for Rational Design of Personalized Therapeutics.
复制标题
DOI：
10.1128/msystems.00173-17
复制
发表时间：
2018-03
期刊：
影响因子：
6.4
通讯作者：
Theriot CM
中科院分区：
文献类型：
--
作者：
Theriot CM
在过去的10年里，微生物组研究一直专注于定义与多个系统中不同疾病状态相关的结构，但未能显示因果关系。以前的组学研究已经产生了许多新的假设，但向前迈进，我们需要开始解剖每种细菌单独的功能，并与表征良好的系统中的复杂细菌群落相结合。在过去的10年里，微生物组研究一直专注于定义与多个系统中不同疾病状态相关的结构，但未能显示因果关系。以前的组学研究已经产生了许多新的假设，但向前迈进，我们需要开始解剖每种细菌单独的功能，并与表征良好的系统中的复杂细菌群落相结合。在接下来的5年里，我们需要将新的组学技术与经典的细菌遗传学、细菌生理学、蛋白质工程和生物化学结合起来进行探索性研究，以进一步确定肠道微生物群的生化机制。系统微生物学领域的未来将专注于微生物组的靶向工程和编辑，以改变功能，这将用于预防和/或治疗人类疾病。这个观点将集中在我对微生物组领域的贡献，无论是过去还是现在，以及我认为该领域的研究在不久的将来会走向何方。
Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems. Over the past 10 years, microbiome research has focused on defining the structures associated with different disease states in multiple systems, but has fallen short on showing causation. Prior omic studies have generated many new hypotheses, but moving forward we need to start dissecting the function of each bacterium alone and in concert with complex bacterial communities in well-characterized systems. Over the next 5 years, we need a merging of new omic technologies for exploratory studies with classical bacterial genetics, bacterial physiology, protein engineering, and biochemistry to further define the biochemical mechanisms of the gut microbiota. The future of the systems microbiology field will focus on targeted engineering and editing of the microbiome to alter function, which will be leveraged to prevent and/or treat human diseases. This perspective will focus on my contribution to the microbiome field, both past and present, and where I think research in the field is headed in the near future.