Recruitment and retention: factors that affect pericyte migration.
Recruitment and retention: factors that affect pericyte migration.
复制标题
DOI：
10.1007/s00018-013-1432-z
复制
发表时间：
2014-01
影响因子：
8
通讯作者：
Brekken, Rolf A.
中科院分区：
文献类型：
--
作者：
Aguilera, Kristina Y.;Brekken, Rolf A.
周细胞对血管形态发生至关重要，并有助于多种病理，包括癌症的发展和进展。周细胞迁移和分化的机制是复杂的，尚未完全建立。目前的文献表明，血小板衍生生长因子/血小板衍生生长因子受体-β、1-磷酸鞘氨醇/内皮分化基因-1、具有免疫球蛋白样和EGF样结构域2的血管生成素-1/酪氨酸激酶、具有免疫球蛋白样和EGF样结构域2的血管生成素-2/酪氨酸激酶、转化生长因子β/激活素受体样激酶1、转化生长因子β/激活素受体样激酶5、脑信号蛋白-3A/神经纤毛蛋白和基质金属蛋白酶活性调节周细胞向新生血管的募集。有趣的是，这些途径中的许多直接受到分泌的酸性蛋白质和富含半胱氨酸（Cys）的影响。在这里，我们总结了这些因素在周细胞迁移的功能，并讨论如果以及如何影响这些活动，从而提供了一个额外的控制层的招聘血管支持细胞。此外，有针对性地抑制周细胞在肿瘤和目前的理解周细胞招聘病理环境中的后果进行了讨论。
Pericytes are critical for vascular morphogenesis and contribute to several pathologies, including cancer development and progression. The mechanisms governing pericyte migration and differentiation are complex and have not been fully established. Current literature suggests that platelet-derived growth factor/platelet-derived growth factor receptor-β, sphingosine 1-phosphate/endothelial differentiation gene-1, angiopoietin-1/tyrosine kinase with immunoglobulin-like and EGF-like domains 2, angiopoietin-2/tyros-ine kinase with immunoglobulin-like and EGF-like domains 2, transforming growth factor β/activin receptor-like kinase 1, transforming growth factor β/activin receptor-like kinase 5, Semaphorin-3A/Neuropilin, and matrix metalloproteinase activity regulate the recruitment of pericytes to nascent vessels. Interestingly, many of these pathways are directly affected by secreted protein acidic and rich in cysteine (SPARC). Here, we summarize the function of these factors in pericyte migration and discuss if and how SPARC might infuence these activities and thus provide an additional layer of control for the recruitment of vascular support cells. Additionally, the consequences of targeted inhibition of pericytes in tumors and the current understanding of pericyte recruitment in pathological environments are discussed.
登录
查看更多内容
影响因子：
8
作者：
Chlenski, A.;Guerrero, L. J.;Cohn, S. L.
通讯作者：
Cohn, S. L.
影响因子：
20.1
作者：
Cho, A;Reidy, MA
通讯作者：
Reidy, MA
影响因子：
15.9
作者：
Abramsson, A;Lindblom, P;Betsholtz, C
通讯作者：
Betsholtz, C
影响因子：
20.3
作者：
Allende, ML;Yamashita, T;Proia, RL
通讯作者：
Proia, RL
影响因子：
4.6
作者：
Bolton C
通讯作者：
Bolton C