Adenomatous lesions of the large bowel: An autopsy survey
Adenomatous lesions of the large bowel: An autopsy survey
复制标题
大肠腺瘤性病变：尸检调查
作者：
R. Rickert;O. Auerbach;L. Garfinkel;E. Hammond;J. M. Frasca
一项全面的大肠解剖调查显示，腺瘤是非常常见的病变，在518例研究病例中约有一半发生。绝大多数为小腺瘤性息肉（管状腺瘤），86.7%直径小于10mm。更复杂的管状-绒毛型腺瘤较大，平均直径为19.0 mm。随着年龄的增长，腺瘤的平均大小没有明显增加。发现了19例临床未怀疑的癌症。14例（8例原位癌，6例浸润性癌）存在残留的良性腺瘤。5例浸润性癌症没有残留的良性成分。未发现原位癌或小（< 10mm）浸润性癌，未发现腺瘤残留。结果表明，虽然大肠腺瘤很常见，但绝大多数是单纯的腺瘤性息肉，不会发生进行性生长和恶性变化。相反，良性腺瘤具有较大的体积和更复杂的绒毛结构。
A comprehensive autopsy survey of the large bowel showed that adenomas were very common lesions occurring in about one‐half of the 518 cases studied. The great majority were small adenomatous polyps (tubular adenomas), 86.7% measuring less than 10 mm in diameter. Adenomas with a more complex tubulo‐villous pattern were larger with a mean diameter of 19.0 mm. There was no apparent increase in mean size of adenomas with age. Nineteen clinically unsuspected cancers were discovered. Fourteen (8 in situ and 6 invasive) cancers had areas of residual benign adenoma. Five invasive cancers had no residual benign component. No in situ carcinomas or small (<10 mm) invasive cancers not containing residual adenoma were found. The results suggest that, although adenomas of the large bowel are very common, the vast majority are simple adenomatous polyps which do not undergo progressive growth and malignant change. Conversely, it appears that cancers may arise from benign adenomas which have the characteristics of large size and a more complex villous architecture.