Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.
Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.
复制标题
将胆碱能免疫毒素 ME20.4IgG-saporin 注射到猴子的 Broca 对角带、Meynert 基底核或两者后，对学习能力产生不同的影响。
DOI：
10.1037//0735-7044.113.2.303
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发表时间：
1999
影响因子：
1.9
通讯作者：
Harry F. Baker
中科院分区：
文献类型：
--
作者：
Rosalind M. Ridley;H. C. Barefoot;C. J. Maclean;P. Pugh;Harry F. Baker
猴Broca斜角带(VDB)的免疫毒性损伤扰乱了向海马区的胆碱能输入，导致对视觉空间条件辨别的学习受损，而不是简单的视觉辨别。免疫毒性损毁Meynert基底核(NBM)剥夺了大脑皮层的大部分胆碱能输入，导致对简单视觉辨别的学习受损，但对视觉空间条件性辨别没有影响。NBM+VDB的联合损害导致两种类型任务的学习障碍。NBM损伤后的损害随着时间的推移而改善，但可以通过小剂量的谷氨酸阻断药物MK801恢复，在这个剂量下，不会损害正常猴子的简单视觉辨别学习。来自NBM和VDB的胆碱能投射可能分别支持皮质和海马内谷氨酸能锥体细胞通路的功能。
Immunotoxic lesions of the diagonal band of Broca (VDB) in monkeys disrupted cholinergic input to the hippocampus, producing impaired learning of visuospatial conditional discriminations but not simple visual discriminations. Immunotoxic lesions of the basal nucleus of Meynert (NBM) deprived the cortex of most of its cholinergic input, producing impaired learning of simple visual discriminations but not visuospatial conditional discriminations. Combined lesions of the NBM + VDB resulted in impaired learning of both types of task. The impairment after NBM lesions ameliorated with time but could be reinstated by a low dose of the glutamate blocking drug MK801, which, at this dose, did not impair simple visual discrimination learning in normal monkeys. The cholinergic projections from the NBM and VDB may sustain the function of the glutamatergic pyramidal cell pathways within the cortex and hippocampus, respectively.