Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma.
Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma.
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DOI：
10.1016/j.wjorl.2016.05.011
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Arshad H
中科院分区：
文献类型：
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作者：
Mimikos C;Shafirstein G;Arshad H
光动力疗法在治疗早期头颈鳞状细胞癌（SCC）方面显示出良好的前景。在光动力疗法 (PDT) 中，光敏药物（光敏剂）和可见光通过产生单线态氧和自由基来导致癌细胞死亡，从而引发免疫反应和血管塌陷。在本文中，我们回顾了几项研究，这些研究证明了 PDT 在治疗早期头颈部鳞状细胞癌方面的有效性，其中一些研究显示出类似的手术反应率。通过两个案例来说明PDT的有效性。然后，讨论了新的进展，包括发现 STAT3 交联作为 PDT 反应的潜在生物标志物和局部晚期癌症的间质 PDT。
Photodynamic therapy has shown promise in the treatment of early head and neck squamous cell carcinoma (SCC). In photodynamic therapy (PDT), a light sensitive drug (photosensitizer) and visible light cause cancer cell death by the creation of singlet oxygen and free radicals, inciting an immune response, and vascular collapse. In this paper, we review several studies that demonstrate the effectiveness of PDT in the treatment of early stage SCC of the head and neck, with some showing a similar response rate to surgery. Two cases are presented to illustrate the effectiveness of PDT. Then, new advances are discussed including the discovery of STAT3 crosslinking as a potential biomarker for PDT response and interstitial PDT for locally advanced cancers.