Epigenetic transgenerational actions of endocrine disruptors and mate fertility
Epigenetic transgenerational actions of endocrine disruptors and mate fertility
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DOI：
10.1126/science.1108190
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发表时间：
2005-06-03
期刊：
影响因子：
56.9
通讯作者：
Skinner, MK
中科院分区：
文献类型：
--
作者：
Anway, MD;Cupp, AS;Skinner, MK
环境毒素的跨代效应需要染色体或生殖系的表观遗传改变。在性腺性别测定期间，将怀孕的雌性大鼠短暂暴露于内分泌干扰物vinclozolin（一种抗雄激素化合物）或甲氧基氯（一种雌激素化合物）中，会导致F-1代的成年表型：生精能力（细胞数量和活力）下降，配偶不育发生率增加。这些影响通过配偶生殖系转移到几乎所有后代的配偶身上（即F-1到F-4）。对生殖的影响与生殖系DNA甲基化模式的改变有关。环境因素（例如，内分泌干扰物）重编程生殖系和促进跨代疾病状态的能力对进化生物学和疾病病因学具有重要意义。
Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F-1 generation of decreased spermatogenic capacity (cell number and viability) and increased incidence of mate infertility. These effects were transferred through the mate germ line to nearly all mates of ail subsequent generations examined (that is F-1 to F-4). The effects on reproduction correlate with altered DNA methylation patterns in the germ line. The ability of an environmental factor (for example, endocrine disruptor) to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.