Spectral domain optical coherence tomography imaging of geographic atrophy margins.
Spectral domain optical coherence tomography imaging of geographic atrophy margins.
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DOI：
10.1016/j.ophtha.2009.04.015
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发表时间：
2009-09
期刊：
影响因子：
13.7
通讯作者：
Toth CA
中科院分区：
文献类型：
--
作者：
Bearelly S;Chau FY;Koreishi A;Stinnett SS;Izatt JA;Toth CA
在体内测试光谱域光学相干断层扫描（SDOCT）是否提供了足够的分辨率，可重复测量地图状萎缩（GA）边缘的光感受器（PR）层，以及它是否描绘了PR层和GA边缘的视网膜色素上皮（RPE）之间的关系。前瞻性连续病例系列。2006年1月3日至2007年6月3日在杜克眼科中心进行常规随访期间发现的继发于非新生血管性年龄相关性黄斑变性（AMD）的GA患者，且同意参加本研究。使用光谱域光学相干断层扫描（SDOCT）对眼睛进行成像。保存每只眼睛的多次B扫描，并由2名分级员独立分级，标记以下位置：1）PR厚度开始下降至基线以下的部位，2）PR层消失的部位，以及3）GA边缘部位。对这些数据进行处理以计算PR损失相对于GA边界的位置，并将其分类为A）桥接GA边界，B）完全在GA边界内，或C）完全在GA边界外。计算PR损失的位置（跨GA边缘桥接、完全在GA边缘内或完全在GA边缘外）。测量PR损失开始和结束时与GA边缘的距离。观察者之间的协议，确定PR损失的类别，以及PR损失的位置相对于GA利润。分析了500个独特的扫描。PR丢失最常发生在跨GA边缘的桥接（65%扫描），第二最常发生在完全在GA边缘内（29%扫描），并且最不常发生在完全在GA边缘外（6%扫描）。PR损失开始于GA边缘外的平均61μm [标准差（SD）± 235 μm]，结束于GA边缘内的平均311 μm（SD ± 273 μm），跨越平均372 μm（SD ± 179 μm）。SDOCT提供了足够的分辨率来量化非新生血管性AMD伴GA患者相对于GA边缘的PR损失。它也可以作为未来干预性试验中跟踪疾病进展的一种手段。
To test in vivo whether spectral domain optical coherence tomography (SDOCT) provides adequate resolution for reproducible measurement of photoreceptor (PR) layer at the margins of geographic atrophy (GA), and if it delineates the relationship between PR layer and retinal pigment epithelium (RPE) at the margins of GA. Prospective consecutive case series. Patients with GA secondary to non-neovascular age-related macular degeneration (AMD) identified during routine follow-up at Duke Eye Center between 1/3/06 to 6/3/07 and who consented to participate in this study. Spectral domain optical coherence tomography (SDOCT) was used to image eyes. Multiple B-scans from each eye were saved and independently graded by 2 graders and the following locations were marked: 1) site where PR thickness began to decline below its baseline, 2) site where PR layer disappeared, and 3) site of the GA margin. These data were processed to calculate the locations of PR losses relative to GA margins and were categorized as A) bridging across GA margins, B) entirely within GA margins, or C) entirely outside GA margins. Location of PR loss (bridging across GA margins, entirely within GA margins, or entirely outside GA margins) was calculated. Distances from the GA margin were measured for beginning and ending of PR loss. Interobserver agreement was determined for categories of PR loss as well as locations of PR loss relative to the GA margin. 500 unique scans were analyzed. PR loss occurred most frequently bridging across the GA margin (65% scans), second most frequently entirely inside the GA margin (29% scans), and least frequently entirely outside the GA margin (6% scans). PR loss started an average of 61μm [standard deviation (SD) ± 235 μm] outside the GA margin, ended an average of 311 μm (SD ± 273 μm) inside the GA margin, and spanned an average of 372 μm (SD ± 179 μm). SDOCT provides adequate resolution for quantifying PR loss relative to GA margins in non-neovascular AMD with GA. It may also serve as a means of tracking disease progression in future interventional trials.
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