Effect of correction of metabolic acidosis on bone mineralisation rates in patients with renal osteomalacia.
Effect of correction of metabolic acidosis on bone mineralisation rates in patients with renal osteomalacia.
复制标题
纠正代谢性酸中毒对肾性骨软化症患者骨矿化率的影响。
作者：
M. Cochran;R. Wilkinson
在肾性骨软化症的发生代谢性酸中毒的作用进行了研究，通过研究骨矿化和骨吸收率与联合同位素和平衡技术在6例患者，之前和之后的管理碱。在5例病例中实现了血液pH值的校正，并与骨矿化率的显著上升和钙平衡的显著正趋势相关。这表明，酸中毒有助于肾功能衰竭骨软化症的发病机制，减缓骨骼矿化，可能是通过抑制骨碱性磷酸酶。
The role of metabolic acidosis in the genesis of renal osteomalacia was investigated by studying bone mineralisation and resorption rates with a combined isotope and balance technique in six patients, before and after the administration of alkali. Correction of blood pH was achieved in five cases and was associated with a significant rise in the bone mineralisation rates and a significant positive trend in the calcium balances. It is suggested that acidosis contributes to the pathogenesis of osteomalacia in renal failure by slowing skeletal mineralisation, possibly by inhibiting bone alkaline phosphatase.