Representation of continuous hand and arm movements in macaque areas M1, F5, and AIP: a comparative decoding study
Representation of continuous hand and arm movements in macaque areas M1, F5, and AIP: a comparative decoding study
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DOI：
10.1088/1741-2560/12/5/056016
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发表时间：
2015-10-01
影响因子：
4
通讯作者：
Scherberger, Hansjoerg
中科院分区：
文献类型：
--
作者：
Menz, Veera Katharina;Schaffelhofer, Stefan;Scherberger, Hansjoerg
目标。在过去的十年里，关于多个大脑区域对手臂或手连续动作的解码能力进行了研究。到目前为止，这些研究主要集中在运动或运动前区域，如M1和F5。然而，越来越多的证据表明，顶叶皮质的前顶叶内区(AIP)也包含有关持续运动的信息。接近。在这项研究中，我们从两只猕猴(猕猴)M1、F5和AIP区同时记录的活动中，解码了27个自由度，代表了延迟抓取任务中完整的手和手臂运动学。主要结果。我们发现，所有这三个领域提供的解码性能都明显高于机会。特别是，M1的解码精度最高，其次是F5和AIP。此外，我们支持这样的概念，即AIP不仅编码要抓取的对象的分类视觉特征，而且还包含大量的时间运动学信息。意义重大。这一事实可以用于未来恢复手和手臂运动的神经接口的开发。
Objective. In the last decade, multiple brain areas have been investigated with respect to their decoding capability of continuous arm or hand movements. So far, these studies have mainly focused on motor or premotor areas like M1 and F5. However, there is accumulating evidence that anterior intraparietal area (AIP) in the parietal cortex also contains information about continuous movement. Approach. In this study, we decoded 27 degrees of freedom representing complete hand and arm kinematics during a delayed grasping task from simultaneously recorded activity in areas M1, F5, and AIP of two macaque monkeys (Macaca mulatta). Main results. We found that all three areas provided decoding performances that lay significantly above chance. In particular, M1 yielded highest decoding accuracy followed by F5 and AIP. Furthermore, we provide support for the notion that AIP does not only code categorical visual features of objects to be grasped, but also contains a substantial amount of temporal kinematic information. Significance. This fact could be utilized in future developments of neural interfaces restoring hand and arm movements.