MICROVASCULAR PRESSURE DISTRIBUTION IN SKELETAL-MUSCLE AND EFFECT OF VASODILATION
MICROVASCULAR PRESSURE DISTRIBUTION IN SKELETAL-MUSCLE AND EFFECT OF VASODILATION
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DOI：
10.1152/ajplegacy.1975.228.3.791
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发表时间：
1975-01-01
影响因子：
--
通讯作者：
ZWEIFACH, BW
中科院分区：
文献类型：
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作者：
FRONEK, K;ZWEIFACH, BW
在戊巴比妥麻醉的猫中，对188只极薄肌进行了直接微血管压力和直径测量。直径为70 μ m或更大的小动脉中的微血管压力与体循环动脉压（PA）成正比。直径范围为35至20 μ m的小动脉已被证明是调节下游微压的小动脉阻力的主要来源。穿过毛细管床本身，压降约为PA的15%。最小微静脉（8-15 μ m）的微压平均为24 mmHg，并密切反映毛细血管血压。以微血管基础数据为背景，分析罂粟碱（P）和异丙肾上腺素（IPR）对骨骼肌的舒张作用机制。管理IPR降低小动脉和小静脉的压力，而P输注降低了直径大于20 μ m的小动脉的压力，但是，在较小的小动脉有一个显着的微压升高。数据确定了对末端脉管系统的两种基本上不同的血管舒张作用：一种是毛细血管压力和液体过滤（P）增加，另一种是毛细血管压力增强吸收（IPR）降低。
In cats anesthetized with pentobarbital, 188 direct microvascular pressure and diameter measurements were made of the tenuissimus muscle. The microvascular pressure in arterioles of 70 mum in diameter or larger was proportional to the systemic arterial pressure (PA). The arterioles with diameter-s ranging from 35 to 20 mum have been shown to be the principa-l source of arteriolar resistance regulating micropressures downstream. Across the capillary bed proper, the drop in pressures was about 15% of PA. Micropressures in the smallest venules (8-15 mum) averaged 24 mmHg and reflect closely capillary blood pressure. With a background of basic microvascular data, the vasodilatory mechanism of papaverine (P) and isoproterenol (IPR) in the skeletal muscle was analyzed. Administration of IPR decreases both arteriolar and venular pressure, while P infusion decreased the pressure in arterioles wider than 20 mum in diameter; however, in smaller arterioles there was a substantial elevation in micropressure. The data establish two basically different vasodilatory effects on the terminal vasculature: one with increased capillary pressure and fluid filtration (P), a second with a decrease in capillary pressure enhancing absorption (IPR).