18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry
18F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with 18F-FDG PET and immunohistochemistry
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DOI：
10.1007/s12149-010-0398-2
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发表时间：
2010-10-01
影响因子：
2.6
通讯作者：
Endo, Keigo
中科院分区：
文献类型：
--
作者：
Miyashita, Go;Higuchi, Tetsuya;Endo, Keigo
目的L-3-[F-18]-氟-α-甲基酪氨酸（FAMT）通过L-型氨基酸转运蛋白1（LAT 1）转运入癌细胞。本研究旨在探讨口腔鳞状细胞癌（OSCC）中FAMT和FDG的摄取与Ki-67标记指数（Ki-67 LI）测定的细胞增殖活性之间的关系。所有病例均在术前4周内进行FAMT-PET和FDG-PET。采用半定量分析法比较FAMT和FDG摄取与原发肿瘤最大标准摄取值（SUVmax）的关系。结果FAMT-PET对原发肿瘤的敏感性为84%，而FDG-PET的敏感性为88%。在所有可见病变中，通过平均SUVmax确定的平均FDG摄取为9.7（范围4.2-15.9），平均FAMT摄取为3.5（范围1.3-8.5）。FAMT的SUVmax与Ki-67 LI的相关性（r = 0.878）优于FDG（r = 0.643）。FAMT-PET可作为评价口腔鳞状细胞癌肿瘤增殖的有效方法。
Objective L-3-[F-18]-fluoro-alpha-methyl tyrosine (FAMT) is transported into cancer cells by L-type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate the uptake of FAMT and FDG with the cellular proliferative activity measured by the Ki-67 labeling index (Ki-67 LI) in oral squamous cell carcinoma (OSCC).Methods Twenty-five patients with OSCC were enrolled in this study. Both FAMT-PET and FDG-PET were performed within 4 weeks before surgery in all cases. The uptake of FAMT and FDG was compared by semiquantitative analysis with maximal standardized uptake values (SUVmax) of the primary tumors. Ki-67 LI of the tumors was analyzed by immunohistochemical staining and correlated with the clinicopathologic variables and the uptake of PET tracers.Results For primary tumor detection, FAMT-PET exhibited a sensitivity of 84%, whereas that of FDG-PET was 88%. In all visible lesions, mean FDG uptake determined by average SUVmax was 9.7 (range 4.2-15.9) and mean FAMT uptake was 3.5 (range 1.3-8.5). The SUVmax of FAMT tended to show a better correlation with Ki-67 LI (r = 0.878) than that of FDG (r = 0.643).Conclusions Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation of OSCC.