Nuclear transport: a switch for the oxidative stress-signaling circuit?
Nuclear transport: a switch for the oxidative stress-signaling circuit?
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DOI：
10.1155/2012/208650
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Stochaj U
中科院分区：
文献类型：
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作者：
Kodiha M;Stochaj U
活性氧（ROS）的形成和清除失衡可导致氧化应激和随后的变化，影响生理的各个方面。为了限制和修复ROS产生的损伤，细胞产生了多种反应。这些反应的一个标志是信号通路的激活，调节下游目标在不同的细胞位置的功能。为此，发生在细胞核和细胞质中的应激反应的关键步骤必须协调，这使得两个区室之间的适当通信成为必要。在这里，我们讨论了ros介导的信号和大分子在核膜上的转运之间的相互依存关系。我们强调氧化剂依赖核运输的例子，并描述氧化应激对运输装置的影响。本文最后提出了ros诱导的细胞信号传导、核转运和修复回路。
Imbalances in the formation and clearance of reactive oxygen species (ROS) can lead to oxidative stress and subsequent changes that affect all aspects of physiology. To limit and repair the damage generated by ROS, cells have developed a multitude of responses. A hallmark of these responses is the activation of signaling pathways that modulate the function of downstream targets in different cellular locations. To this end, critical steps of the stress response that occur in the nucleus and cytoplasm have to be coordinated, which makes the proper communication between both compartments mandatory. Here, we discuss the interdependence of ROS-mediated signaling and the transport of macromolecules across the nuclear envelope. We highlight examples of oxidant-dependent nuclear trafficking and describe the impact of oxidative stress on the transport apparatus. Our paper concludes by proposing a cellular circuit of ROS-induced signaling, nuclear transport and repair.