Functional changes in the frontal cortex in Parkinson's disease using a rat model
Functional changes in the frontal cortex in Parkinson's disease using a rat model
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DOI：
10.1016/j.jocn.2009.07.101
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发表时间：
2010-05-01
影响因子：
2
通讯作者：
Liu, Shuwei
中科院分区：
文献类型：
--
作者：
Hou, Zhongyu;Lei, Hao;Liu, Shuwei
近年来，对帕金森病（PD）发病机制的研究主要集中在基底节区。然而，最近的研究证实，PD的病理变化伴随着大脑皮层的功能性运动改变。在大鼠右侧黑质注射6-羟基多巴胺和抗坏血酸。在这种帕金森病大鼠模型中，磁共振波谱显示，右额叶皮层病变中N-乙酰天冬氨酸与肌酸的比例显着低于对照组大鼠的相同比例。PD模型大鼠和对照组大鼠右额叶皮层损伤中胆碱与肌酸的比例无显著差异。损伤侧神经丝蛋白和突触素阳性部位的光密度值较对照组和非损伤侧均显著降低。损伤侧额叶皮质突触密度较未损伤侧减少。突触前膜有异常改变。突触后膜和突触小泡消失，损伤侧典型的突触结构消失。我们假设PD模型大鼠额叶皮层损伤侧出现神经元和突触丢失、突触结构异常以及额叶皮层神经元和突触功能障碍。这些变化可能在PD的发病机制中起重要作用。(C)2009爱思唯尔有限公司保留所有权利。
In recent years, investigations of the pathologic mechanism of Parkinson's disease (PD) have mainly concentrated on the basal ganglia. However, recent studies have confirmed that pathological changes in PD are accompanied by functional motor changes of the cerebral cortex. Rats were injected with 6-hydroxydopamine and ascorbic acid in the right substantia nigra. In this rat model of PD, magnetic resonance spectroscopy showed the ratio of N-acetyl-aspartic acid to creatine in a lesion in the right frontal cortex was significantly lower than the same ratio in a control group of rats. The ratio of choline to creatine in a lesion in the right frontal cortex was not significantly different between the PD-model rats and control rats. In addition, the optical densities of neurofilament protein and synaptophysin positive sites decreased significantly on the side of the brain with the injury compared with the side without the injury, and with both sides in the control rats. The density of synapses in the frontal cortex on the lesioned side was decreased compared with the unlesioned side. There were abnormal changes in the presynaptic membrane. postsynaptic membrane and synaptic vesicles, and the typical synaptic structure was no longer apparent on the lesioned side. We hypothesized loss of neurons and synapses, abnormal synaptic structure and neuron and synaptic dysfunction of the frontal cortex with a lesion in the injury side of the frontal cortex in PD-model rats. These changes might have an important role in the pathologic mechanism of PD. (C) 2009 Elsevier Ltd. All rights reserved.