Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials
Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials
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DOI：
10.1016/j.clnu.2014.03.009
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发表时间：
2015-02-01
影响因子：
6.3
通讯作者：
Huang, Daifa
中科院分区：
文献类型：
--
作者：
Liu, Yanxia;Ma, Wanqiang;Huang, Daifa
背景和目标：研究白藜芦醇对血压影响的人体临床试验结果不一致。方法：我们对PubMed、EMBASE、MEDLINE和科克伦图书馆（更新至2014年1月）中评价白藜芦醇对收缩压（SBP）和舒张压（DBP）影响的随机对照试验进行了策略性文献检索。使用Jadad量表评估研究质量。使用固定效应或随机效应模型计算SBP和DBP净变化的加权平均差异。我们进行了预先指定的亚组，敏感性和荟萃回归分析，以评估潜在的异质性。白藜芦醇对收缩压和舒张压的剂量效应进行了估计，使用meta-回归analysis.Results：六个研究，共包括247名受试者被纳入我们的荟萃分析。荟萃分析的总体结果表明，白藜芦醇的消费不能显着降低SBP和DBP。亚组分析显示，高剂量白藜芦醇摄入（>= 150 mg/d）显著降低SBP为-11.90 mmHg（95% CI：-20.99，-2.81 mmHg，P = 0.01），而低剂量白藜芦醇对SBP无显著降低作用。荟萃回归分析没有表明剂量效应的白藜芦醇对SBP或DBP。结论：目前的荟萃分析表明，白藜芦醇消费显着降低SBP水平在较高的剂量，而白藜芦醇对DBP水平没有显着影响。需要更多的高质量研究来进一步评估因果关系结论。(C)2014爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims.: The results of human clinical trials that have investigated the effects of resveratrol on blood pressure are inconsistent. We aimed to quantitatively evaluate the effects of resveratrol on systolic blood pressure (SBP) and diastolic blood pressure (DBP).Methods: We conducted a strategic literature search of PubMed, EMBASE, MEDLINE, and the Cochrane Library (updated to January, 2014) for randomized controlled trials that evaluate the effects of resveratrol on SBP and DBP. Study quality was assessed using the Jadad scale. Weighted mean differences were calculated for net changes in SBP and DBP using fixed-effects or random-effects models. We performed pre-specified subgroup, sensitivity and meta-regression analyses to evaluate potential the heterogeneity. Dose effects of resveratrol on SBP and DBP were estimated using meta-regression analyses.Results: Six studies comprising a total of 247 subjects were included in our meta-analysis. The overall outcome of the meta-analysis indicates that resveratrol consumption can not significantly reduce SBP and DBP. Subgroup analyses indicated that higher-dose of resveratrol consumption (>= 150 mg/d) significantly reduces SBP of -11.90 mmHg (95% CI: -20.99, -2.81 mmHg, P = 0.01), whereas lower dose of resveratrol did not show a significant lowering effect on SBP. The meta-regression analyses did not indicate dose effects of resveratrol on SBP or DBP.Conclusions: The present meta-analysis indicates that resveratrol consumption significantly decreases the SBP level at the higher dose, while resveratrol has no significant effects on DBP levels. Additional high-quality studies are needed to further evaluate the causal conclusions. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.