Tumor Heterogeneity--A 'Contemporary Concept' Founded on Historical Insights and Predictions.
Tumor Heterogeneity--A 'Contemporary Concept' Founded on Historical Insights and Predictions.
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DOI：
10.1158/0008-5472.can-15-3024
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发表时间：
2016-01-01
期刊：
影响因子：
11.2
通讯作者：
Welch DR
中科院分区：
文献类型：
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作者：
Welch DR
异质性在所有癌症类型中以及在几个水平上是常见的-内在的（遗传的）、表观遗传的、位置的和在群体水平上。具有肿瘤块的不同亚群彼此通信，并在局部和远处影响其他肿瘤细胞的行为。这些特性对于理解肿瘤行为以及如何（或应该）进行治疗具有深远的意义。这篇简短的评论突出了对格洛丽亚赫普纳的有见地的评论，以及它如何影响癌症研究，甚至在它出版三十年后。
Heterogeneity is commonplace in all cancer types and at several levels – intrinsic (genetic), epigenetic, positional and at the population level. The different subpopulations with a tumor mass communicate with each other and influence the behavior of other tumor cells both locally and at a distance. These properties have profound implications regarding the understanding of tumor behavior and how therapies are (or should be) administered. This brief commentary highlights the insightful review of Gloria Heppner and how it has influenced cancer research even three decades after it was published.