Experimental studies on fluid pathophysiology in small intestinal obstruction in the rat. I. Effects of intraluminal hyperosmolality.
Experimental studies on fluid pathophysiology in small intestinal obstruction in the rat. I. Effects of intraluminal hyperosmolality.
复制标题
大鼠小肠梗阻液体病理生理学的实验研究。
DOI：
--
复制
发表时间：
1978
影响因子：
1.9
通讯作者：
G. Nylander
中科院分区：
文献类型：
--
作者：
L. Johnson;H. Nordström;G. Nylander
描述了一种实验模型，其目的是模拟和强调由简单的小肠梗阻引起的穿过肠粘膜的流体的运动，以及提供用于测量这些流体转移的手段。假设阻塞小肠中的液体增加是肠内容物酶分解导致的渗透压增加的结果，将高渗透压溶液引入已知大小和位置的肠段中。在这些条件下，肠粘膜以半透膜的方式起作用，并且仅允许低渗透压的流体进入肠腔，从而趋于使其高渗透压含量正常化。稀释过程遵循简单的稀释曲线。同时，血液浓缩和血清渗透压升高反映了液体从血管外和血管腔室的动员。在整个试验期间，液体持续转移到肠腔中，尽管管腔内压力线性增加至相对较高的水平，表明平滑肌张力增加可能是由于高渗激发所致。观察到的液体蓄积具有良好的重现性，并与对血管和血管外隔室的可预测影响相关。
An experimental model is described which is intended to simulate and accentuate the movement of fluids across the intestinal mucosa resulting from simple small intestinal obstruction as well as to provide a means for measuring these fluid shifts. Working on the hypothesis that the increase in fluid in the obstructed small intestine is a consequence of increased osmolality resulting from enzymatic breakdown of the intestinal contents, a solution of high osmolality was introduced into an intestinal segment of known size and position. Under these conditions the intestinal mucosa functioned in the manner of a semipermeable membrane and permitted only fluids of low osmolality to enter the intestinal lumen, thus tending to normalize its hyperosmolal contents. The process of dilution followed a simple dilution curve. At the same time hemoconcentration and increased serum osmolality reflected the mobilization of fluids from the extravascular and vascular compartments. The transfer of fluids into the intestinal lumen continued throughout the test period, despite the fact that there was a linear increase in intraluminal pressure to a relatively high level, indicating increased smooth muscle tone probably due to the hyperosmolal provocation. The observed accumulation of fluid was well reproducible and associated with predictable effects on the vascular and extra-vascular compartments.