THE OXYGEN DISSOCIATION CURVE IN ANEMIA OF VARIOUS TYPES
THE OXYGEN DISSOCIATION CURVE IN ANEMIA OF VARIOUS TYPES
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DOI：
10.1172/jci103014
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发表时间：
1954-01-01
影响因子：
15.9
通讯作者：
VALTIS, DJ
中科院分区：
文献类型：
--
作者：
KENNEDY, AC;VALTIS, DJ
详细介绍了 29 例贫血病例的 O2 解离曲线观察结果。 11 例复发性巨幼红细胞性贫血病例中的 10 例以及 10 例低色素性继发性贫血病例中的 9 例存在 O2 解离曲线向右移位。 3 例溶血性贫血、治疗性缓解的巨幼细胞贫血或 2 例再生障碍性贫血中的 1 例均未出现右移。通过使用 Henderson-Hasselbalch 方程直接测定细胞 pH 值，作者得出结论，曲线位移的主要部分是由于细胞 pH 值相对于血浆 pH 值的降低所致。
Observations on the O2 dissociation curve in 29 cases of anemia are presented in detail. In 10 of 11 cases of megaloblastic anemia in relapse and in 9 of 10 cases of hypochromlc and secondary anemia there was a displacement of the O2 dissociation curve to the right. No shift to the right was present in 3 cases of hemolytic anemia, in cases of megaloblastic anemia in therapeutic remission, or in 1 of 2 cases of aplastic anemia. From direct determination of the cell pH, using the Henderson-Hasselbalch equation, the authors conclude that the major part of the curve displacement is due to a reduction in ceil pH relative to plasma pH.