The effect of body mass index and its interaction with family history on hypertension: a case-control study
The effect of body mass index and its interaction with family history on hypertension: a case-control study
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DOI：
10.1186/s40885-019-0111-2
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发表时间：
2019-02-21
影响因子：
4.2
通讯作者：
Zhang, Yi-ying
中科院分区：
文献类型：
--
作者：
Li, An-le;Peng, Qian;Zhang, Yi-ying
背景：BMI是国际上常用的衡量身体体重和身高的指标，它反映了获得性生活方式的综合结果；FH是反映遗传因素主要作用的标志。本研究旨在评价BMI及其与FH的相互作用对上海成人高血压风险的影响。方法：本研究采用1∶1配对设计，选取342例病例和342例对照，在中国上海进行。参与者接受了面对面的问卷调查、人体测量测试和实验室检查。计算BMI、腰臀比（WHR）等反映肥胖的相关指标。采用多因素logistic回归分析探讨高血压危险因素之间的关系。通过协同指数（SI）、相互作用的相对超额风险（rei）、相互作用的归因比例（AP）和纯因素之间相互作用的百分比（PAP）来评价相互作用效应。结果：684例28 ~ 87岁的研究对象中，病例组与对照组的平均年龄、平均身高差异无统计学意义（p < 0.05），而体重、WC、HC、BMI、WHR的平均值差异有统计学意义（p < 0.001）。FH对高血压的OR为4.986 (95%CI: 2.832，相似于8.877)；BMI与高血压的比值分别为：低体重为1.528 (95%CI: 0.551，相似于4.239)，超重为3.333 (95%CI: 1.678，相似于6.617)，肥胖为7.312 （95%CI: 3.556，相似于15.035）。FH和BMI与高血压相互作用的OR为12.993 （95%CI: 7.426，相似于22.734）。SI为1.90 (95%CI: 1.48相似于3.78)，RERI为5.67 (95%CI: 1.66相似于11.88)，AP为43.87% (95%CI: 12.84相似于91.88%)，PAP为47.55% （95%CI: 13.91相似于99.58%）。FH与BMI对高血压有正向交互作用。43.87%的高血压暴露于FH和BMI均可归因于两者的相互作用。结论：FH和BMI是高血压的高危因素；BMI越高，患高血压的风险越高。FH和BMI与高血压呈正交互作用，交互作用大于两种独立作用之和。
Background: BMI is an indicator commonly used in the world to measure the weight and height of the body, it reflects the comprehensive outcome of acquired lifestyle; FH is a sign reflecting the main role of genetic factors. This study aimed to evaluate the effect of BMI and interaction with FH on hypertension risk in Shanghai adult population.Methods: According to l:l matched pairs design, 342 cases and 342 controls were selected and investigated in this study, this study was performed in Shanghai, China. Participants received face-to-face questionnaire survey, anthropometric tests and laboratory examinations. Relevant indicators that reflect obesity including BMI and waist to hip ratio (WHR) were calculated. Multivariate logistic regression analysis was applied to explore the association between factors and hypertension risk. Interactive effect was evaluated by synergy index (SI), relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and the percentage of the interaction between the pure factors (PAP).Results: Among 684 study participants aged 28-87 years old, the differences of mean age and height between case group and control group are no significant (p > 0.05), but the differences of mean of weight, WC, HC, BMI and WHR are significant (p < 0.001). The OR of FH on hypertension is 4.986 (95%CI: 2.832 similar to 8.877); the OR of BMI on hypertension is respectively: low weight is 1.528 (95%CI: 0.551 similar to 4.239), overweight is 3.333 (95%CI: 1.678 similar to 6.617) and obesity is 7.312 (95%CI: 3.556 similar to 15.035). The OR of interaction between FH and BMI to hypertension is 12.993 (95%CI: 7.426 similar to 22.734). SI is 1.90 (95% CI: 1.48 similar to 3.78), RERI is 5.67 (95% CI: 1.66 similar to 11.88), AP is 43.87% (95% CI: 12.84 similar to 91.88%), and PAP is 47.55% (95%CI: 13.91 similar to 99.58%). FH and BMI have positive interaction on hypertension. 43.87% of hypertension exposed to both FH and BMI was attributable to the interaction of them.Conclusions: FH and BMI are significant higher risks of hypertension; with the increase of BMI, the risk of hypertension will increase more. FH and BMI have positive interaction with hypertension, the interaction is greater than the sum of two independent actions.