Metabolomics Reveals Altered Lipid Metabolism in a Mouse Model of Endometriosis
Metabolomics Reveals Altered Lipid Metabolism in a Mouse Model of Endometriosis
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DOI：
10.1021/acs.jproteome.6b00197
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发表时间：
2016-08-01
影响因子：
4.4
通讯作者：
Patterson, Andrew D.
中科院分区：
文献类型：
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作者：
Dutta, Mainak;Anitha, Mallappa;Patterson, Andrew D.
子宫内膜异位症是一种常见的慢性雌激素依赖性妇科疾病，约有10%的育龄妇女发生在功能正常的子宫内膜腺体和子宫外基质中。其特征是空洞增生。在本研究中，我们使用基于质谱的脂质组学研究子宫内膜异位症诱导小鼠血脂谱的变化。我们确定了几种失调的脂质，如磷脂酰胆碱，鞘磷脂，磷脂酰乙醇胺和甘油三酯，并表明甘油三酯可能是由于腹膜中的一般炎症条件。我们还表明，除了磷脂酰胆碱的改变，也有一个影响的比例的磷脂酰胆碱/磷脂酰乙醇胺在小鼠血清中诱导的疾病，这种变化可能是由于增加的磷脂酰乙醇胺N-甲基转移酶基因的表达。该研究为子宫内膜异位症的病因学提供了新的见解。
Endometriosis is a common chronic estrogen dependent gynecological disease affecting 10% of women in functional endometrial glands and stroma outside the uterine their reproductive age. It is characterized by proliferation of cavity. In the present study, we used mass spectrometry-based lipidomics to investigate the alterations in serum lipid profiles of mice induced with endometriosis. We identified several dysregulated lipids such as phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, and triglycerides and show that triglycerides may be due to a general inflammatory condition in the peritoneum. We also show that in addition to phosphatidylcholine alteration, there is also an effect in the ratio of phosphatidylcholine/phosphatidylethanolamine in serum of mice induced with the disease and that this change may be due to increased expression of the phosphatidylethanolamine N-methyltransferase gene. The study provides new insight into the etiology of endometriosis.