Physostigmine enhances blood flow-metabolism ratio in neocortex.
Physostigmine enhances blood flow-metabolism ratio in neocortex.
复制标题
毒扁豆碱可增强新皮质的血流代谢比。
作者：
O. Scremin;K. Allen;C. Torres;A. Scremin
用毒扁豆碱单次脉冲抑制中枢神经系统胆碱酯酶可引起新皮层、扣带回、屏状核和杏仁核的血流量显著增加。这种现象并不伴随着能量代谢的增加，这可能有助于解释这种药物对正常人和阿尔茨海默病患者以及其他疾病的记忆的影响。相反，在上级丘（视觉通路的一个组成部分）中观察到血流量和代谢的平行增加。与单次脉冲给药相比，长期给药毒扁豆碱可导致新皮质持续性血管舒张，扣带回、屏状核和杏仁核的这种效应减弱，初级嗅觉皮质和海马增加。毒扁豆碱对葡萄糖利用的影响与脉冲给药基本相同。
Inhibition of central nervous system cholinesterase with a single pulse of physostigmine induces a pronounced increase of blood flow in the neocortex, cingulate gyrus, claustrum, and amygdala. This phenomenon is not accompanied by an increase in energy metabolism and may help explain the effect of this drug on memory in normal humans and patients with Alzheimer's disease, as well as other conditions. In contrast, a parallel increase of blood flow and metabolism was observed in the superior colliculus, a component of the visual pathways. Prolonged administration of physostigmine lead to persistent vasodilatation in the neocortex, a lessening of this effect in cingulate gyrus, claustrum and amygdala, and an increase in primary olfactory cortex and hippocampus when compared with single pulse administration. Effects of physostigmine on glucose utilization remained essentially the same as with pulse administration.